Numark Anti-Diarrhoea (Loperamide Hydrochloride)

Loperamide Hydrochloride, the active ingredient in Numark Anti-Diarrhoea, is an antidiarrheal presented as a tablet for oral use. It reduces the frequency and urgency of loose stools in adults and children.

GNH USA supplies Numark Anti-Diarrhoea as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Loperamide is an antidiarrheal that works on the gastrointestinal motility pathway. It is indicated for: - Acute nonspecific diarrhea: decreases stool frequency and improves consistency. - Traveler's diarrhea: provides symptomatic relief for short‑term travel‑related loose stools. - Chronic diarrhea associated with inflammatory bowel disease: helps control stool output. - Ileostomy output reduction: limits excessive fluid loss in patients with an ileostomy.

Loperamide may cause a range of adverse reactions.

Common Side Effects: - Constipation: reduced bowel movements. - Abdominal cramps: mild to moderate discomfort. - Nausea: feeling of queasiness. - Flatulence: increased intestinal gas. - Dizziness: transient light‑headedness. - Dry mouth: reduced salivation.

Serious or Rare Side Effects: - Severe constipation leading to bowel obstruction. - Toxic megacolon: dangerous colonic dilation. - Allergic reactions: rash, itching, or swelling. - Cardiac arrhythmias: QT prolongation or ventricular tachycardia. - Central nervous system depression when combined with other opioids. - Hepatotoxicity in patients with pre‑existing liver disease.

Before using Numark Anti‑Diarrhoea, consider the following safety points. - Assess hydration status: ensure adequate fluid replacement. - Avoid use in infectious diarrhea: may prolong pathogen shedding. - Do not exceed recommended dose: follow prescriber instructions. - Use with caution in hepatic impairment: metabolism is liver‑dependent. - Monitor for constipation: discontinue if severe. - Store at room temperature: keep in the original pack, protect from moisture.

Loperamide can interact with several medicines.

Major Interactions (Avoid): - CYP3A4 inhibitors (e.g., ketoconazole): increase loperamide plasma levels. - CYP2C8 inhibitors (e.g., gemfibrozil): raise systemic exposure. - Concurrent antidiarrheals: additive slowing of gut motility.

Moderate Interactions (Monitor Closely): - Anticholinergic agents: may exacerbate constipation. - Opioid analgesics: additive central opioid effects. - Rifampin: may reduce loperamide effectiveness. - P-glycoprotein inducers (e.g., St. John’s wort): lower drug concentrations. - QT‑prolonging drugs: increase risk of cardiac arrhythmias.