Nubral (Urea)

Urea, the active ingredient in Nubral, is a keratolytic agent presented as a topical formulation for dermatological use. It helps manage hyperkeratotic skin conditions in adults.

GNH USA supplies Nubral as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Urea is used in dermatology to address disorders involving abnormal keratinization.

- Ichthyosis: reduces scaling and improves skin hydration. - Psoriasis: softens plaques and decreases thickness. - Xerosis (dry skin): restores moisture and smoothness.

Urea is generally well tolerated, but local reactions may occur.

Common Side Effects: - Stinging sensation: mild transient discomfort at the application site. - Burning: brief heat feeling during initial use. - Mild erythema: slight redness that usually resolves. - Itching: occasional pruritus, especially on sensitive skin.

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis): requires immediate medical attention. - Contact dermatitis: persistent rash or swelling. - Skin ulceration: breakdown of skin integrity with prolonged irritation. - Excessive skin peeling: pronounced desquamation beyond expected levels.

Before using Nubral, consider the following safety measures. - Pregnancy: consult a healthcare professional before application. - Breastfeeding: use with caution and under medical advice. - Skin integrity: avoid applying on open wounds or severely damaged skin. - Allergy: discontinue use if hypersensitivity signs appear. - Store at ambient temperature: keep in the original container, protect from moisture and heat.

Urea has limited systemic interactions, but topical combinations may affect tolerability.

Major Interactions (Avoid): - Concurrent use with other keratolytic agents (e.g., salicylic acid) may cause excessive irritation. - None reported: no major drug‑drug interactions identified.

Moderate Interactions (Monitor Closely): - Use with occlusive dressings may increase local irritation. - Combining with topical antibiotics may raise the risk of contact dermatitis. - Application with alcohol‑based products may reduce efficacy.