Nozinan (Levomepromazine Maleate)

Levomepromazine maleate, the active ingredient in Nozinan, is a phenothiazine antipsychotic presented as a tablet for oral use. It is employed in the management of severe agitation, nausea, and pain, particularly in palliative care settings. GNH USA supplies Nozinan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH USA supplies Nozinan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Levomepromazine is a broad‑spectrum phenothiazine that acts on multiple neurotransmitter pathways, providing therapeutic effects in several clinical contexts.

- Severe agitation in terminal illness: helps calm patients who are highly distressed. - Nausea and vomiting associated with chemotherapy: reduces episodes of emesis. - Moderate to severe pain in palliative care: enhances analgesia when combined with opioids. - Schizophrenia resistant to other antipsychotics: offers an alternative when standard agents fail. - Acute psychotic episodes: can be used to rapidly control severe psychotic symptoms.

Levomepromazine may cause a range of adverse reactions, from mild to potentially serious.

Common Side Effects: - Drowsiness: feeling ​the ​most ​common ​sedative ​effect. - Dry mouth: reduced salivation. - Orthostatic hypotension: drop ​in ​blood ​pressure ​upon ​standing. - Constipation: slowed gastrointestinal motility. - Blurred vision: temporary visual disturbances. - Weight gain: increased appetite.

Serious or Rare Side Effects: - Neuroleptic Malignant Syndrome (NMS): A rare, life-threatening reaction causing high fever, severe muscle stiffness, sweating, fast heartbeat, and confusion. - Agranulocytosis: A severe, dangerous drop in white blood cells that increases your risk of serious infections, marked by fever, sore throat, or mouth ulcers. - Heart Rhythm Disorders (QT Prolongation / Torsades de Pointes): Irregular heartbeats, palpitations, dizziness, or fainting linked to changes in the heart's electrical activity. - Severe Orthostatic Hypotension: A sharp drop in blood pressure when standing up, leading to dizziness, lightheadedness, or fainting. - Paralytic Ileus: Severe bowel blockage or lack of gut movement causing long-term constipation, abdominal pain, and bloating. - Severe Allergic Reactions: Anaphylaxis, skin rashes, hives, and swelling of the face, lips, or throat. - Movement Disorders: Long-term or abnormal involuntary muscle movements, tremors, rigidity, and tardive dyskinesia.

Levomepromazine ​      Nozinan (levomepromazine/methotrimeprazine) requires careful medical oversight due to risks of severe low blood pressure, sedation, and temperature regulation problems