Nozinan (Levomepromazine)

Levomepromazine, the active ingredient in Nozinan, is a phenothiazine presented as a tablet for oral use. It is employed in the management of severe agitation, psychotic disorders and palliative care symptom control in adult patients. GNH USA supplies Nozinan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

GNH USA supplies Nozinan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Levomepromazine is a broad‑spectrum antipsychotic that is used across several psychiatric and palliative‑care pathways.

- Schizophrenia: helps alleviate delusions, hallucinations and thought disorder. - Severe agitation or psychomotor excitement: calms acute behavioral disturbances. - Nausea and vomiting in palliative care: reduces refractory nausea when other agents fail. - Chronic pain adjunct: enhances analgesia as part of multimodal regimens. - Pre‑operative anesthesia preparation: provides sedation and anti‑emetic cover. - Delirium in terminal illness: assists in controlling distressing psychomotor symptoms.

Levomepromazine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects: - Drowsiness or sedation - Dry mouth - Constipation - Orthostatic hypotension - Blurred vision - Weight gain

Serious or Rare Side Effects: - Extrapyramidal symptoms (e.g., dystonia, akathisia) - Neuroleptic malignant syndrome - Severe hypotension - Cardiac arrhythmias (QT prolongation) - Agranulocytosis - Hepatic dysfunction

When prescribing Levom­epromazine, clinicians should consider several safety measures.

- Cardiac monitoring: patients with known QT‑prolongation risk should have ECG monitoring. - Metabolic monitoring: watch for weight gain and glucose intolerance. - Hematologic monitoring: periodic blood counts are advised due to rare risk of agranulocytosis. - CNS depression: avoid concurrent CNS depressants that may enhance sedation. - Pregnancy and lactation: use only if benefit outweigh  - Store at below 25°C: keep in the original packaging  - Store at below 

Nozinan (also known as methotrimeprazine or levomepromazine) interacts with many substances, leading to increased drowsiness, low blood pressure, or dangerous heart rhythms. Central Nervous System (CNS) Depressants • Alcohol: Enhances sedation and severe drops in blood pressure; alcohol should be strictly avoided. • Opioids and Painkillers: Can cause extreme drowsiness, breathing difficulties, or severe hypotension. • Sleeping Pills and Anxiety Meds: Medications like benzodiazepines (e.g., lorazepam, alprazolam) multiply sedative effects. • Antihistamines and Muscle Relaxants: Allergy pills and relaxants add to deep drowsiness and slowed reactions. Heart and Blood Pressure Medications • Antihypertensives and ACE Inhibitors: Combining them can cause severe, sudden drops in blood pressure (orthostatic hypotension). • QT-Prolonging Drugs: Drugs that alter heart rhythm (such as certain antiarrhythmics) combined with Nozinan raise the risk of dangerous irregular heartbeats. • Epinephrine: Nozinan can reverse or diminish the blood pressure-raising effects of epinephrine. Liver and Enzyme Interactions (CYP2D6) • CYP2D6 Substrates: Nozinan inhibits the liver enzyme CYP2D6, which can increase levels and side effects of drugs like antidepressants (amitriptyline, nortriptyline) or codeine in the body.