Novostella (Prasterone)

Prasterone, the active ingredient in Novostella, is an androgen presented as an oral formulation for oral use. It is employed in hormone replacement therapy to alleviate menopausal symptoms, improve sexual function, and support patients with adrenal insufficiency.

GNH USA supplies Novostella as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance, and reliable logistics across multiple regions. The company leverages a robust distribution network and adheres to stringent quality standards to meet the needs of healthcare providers in Europe, Asia, Africa and the Americas.

Novostella (prasterone) acts on androgen pathways to address several endocrine‑related conditions.

- Menopausal symptoms: alleviates hot flashes, night sweats and improves mood and vaginal health. - Sexual dysfunction: enhances libido and sexual response in both men and women with hormonal deficits. - Adrenal insufficiency: supports endogenous steroid production, helping to maintain energy and metabolic balance.

Prasterone may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects: - Acne: mild to moderate skin eruptions. - Hair loss: increased shedding or thinning. - Mood changes: irritability or anxiety. - Fluid retention: mild edema in extremities.

Serious or Rare Side Effects: - Hepatotoxicity: elevated liver enzymes or hepatitis. - Hormone‑dependent tumor growth: stimulation of existing prostate or breast neoplasms. - Severe allergic reaction: rash, angioedema or anaphylaxis.

When prescribing Novostella, clinicians should consider several precautionary measures to ensure patient safety.

- Assess baseline hormone levels: evaluate androgen and estrogen status before initiation. - Monitor liver function: periodic testing recommended during therapy. - Screen for hormone‑sensitive cancers: avoid use in patients with active prostate or breast malignancies. - Evaluate cardiovascular risk: consider history of thrombosis or hypertension. - Use caution in elderly: dose adjustments may be required due to altered metabolism. - Store at ambient temperature: keep below 25 °C in original packaging, protected from moisture.

Prasterone can influence the activity of other medications through enzymatic pathways and hormone‑mediated mechanisms.

Major Interactions (Avoid): - CYP3A4 inhibitors: strong inhibitors (e.g., ketoconazole) may increase prasterone levels, risking toxicity. - Hormonal contraceptives: may reduce efficacy of estrogen‑containing birth control.

Moderate Interactions (Monitor Closely): - Anticoagulants: androgenic effects can alter coagulation parameters, requiring INR monitoring. - Antidiabetic agents: changes in insulin sensitivity may necessitate glucose monitoring. - Thyroid hormones: potential alteration of thyroid function tests.