Novesine (Oxybuprocaine Hydrochloride)

Oxybuprocaine Hydrochloride, the active ingredient in Novesine, is a local anesthetic presented as a topical ophthalmic solution for ocular use. It provides reversible surface anesthesia of the eye, facilitating diagnostic examinations and minor procedures by temporarily blocking sensory nerve transmission on the corneal surface.

GNH USA supplies Novesine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across global markets.

Oxybuprocaine Hydrochloride acts on the ocular surface to provide temporary anesthesia for eye examinations and minor procedures. - Diagnostic ocular examinations: enables painless slit‑lamp biomicroscopy and fundus evaluation. - Minor ocular procedures: facilitates foreign body removal, tonometry, and laser treatments. - Contact lens fitting: reduces discomfort during assessment of lens tolerance.

Oxybuprocaine Hydrochloride may cause transient ocular reactions.

Common Side Effects: - Stinging or burning sensation upon instillation. - Temporary blurred vision. - Mild conjunctival hyperemia. - Increased tearing. - Transient corneal epithelial irritation. - Mild headache.

Serious or Rare Side Effects: - Allergic reaction (e.g., rash, swelling, anaphylaxis). - Corneal ulceration or persistent epithelial defect. - Severe ocular inflammation. - Secondary infection of the ocular surface. - Systemic toxicity (rare, with excessive dosing).

When using Novesine, consider the following safety measures. - Allergy assessment: verify no known hypersensitivity to oxybuprocaine or related anesthetics. - Contact lens use: avoid applying before inserting contact lenses. - Duration of use: limit to a single diagnostic procedure unless otherwise directed. - Concurrent ocular medications: assess for potential additive irritation. - Pregnancy and lactation: use only if the benefit outweighs potential risk. - Store at room temperature: keep in the original container, protect from light and moisture.

Oxybuprocaine Hydrochloride may interact with other ophthalmic agents.

Major Interactions (Avoid): - Systemic anesthetics: may potentiate central nervous system depression in rare cases. - Topical vasoconstrictors: can increase local absorption of the anesthetic.

Moderate Interactions (Monitor Closely): - Other ocular anesthetics: additive local anesthetic effect may increase corneal toxicity. - Anticholinergic eye drops: may alter pupil response when combined. - Prolonged corticosteroid use: raises risk of corneal epithelial damage.