Novesine (Oxybuprocaine Hydrochloride)

Oxybuprocaine Hydrochloride, the active ingredient in Novesine, is a local anesthetic (ester type) presented as a sterile ophthalmic solution for ocular use. It provides rapid, reversible numbing of the corneal surface, facilitating diagnostic examinations, minor procedures, and, when deemed appropriate by a qualified eye‑care professional, use in children, ensuring patient comfort.

GNH USA supplies Novesine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export to EU and other markets.

Oxybuprocaine Hydrochloride is used as a topical ocular anesthetic to temporarily block sensation on the eye surface.

Diagnostic eye examinations: provides rapid numbing for slit‑lamp biomicroscopy and other assessment procedures. Foreign body removal: enables painless removal of corneal or conjunctival foreign bodies. Tonometry: allows comfortable intra‑ocular pressure measurement. Laser procedures: facilitates patient comfort during laser photocoagulation or refractive surgery.

Oxybuprocaine Hydrochloride may cause ocular adverse reactions, which are generally mild and transient.

Common Side Effects: - Burning sensation on the eye surface. - Stinging or irritation after instillation. - Conjunctival hyperemia (redness). - Transient blurred vision.

Serious or Rare Side Effects: - Allergic reactions such as angioedema or anaphylaxis. - Corneal ulceration or persistent epithelial defect.

When using Oxybuprocaine Hydrochloride, certain precautions should be observed to minimise risk.

Allergy assessment: avoid use in patients with known hypersensitivity to oxybuprocaine or other ester‑type anesthetics. Contact lens use: remove contact lenses before application and wait before reinserting. Duration of use: limit administration to a single diagnostic procedure unless a specialist advises otherwise. Pediatric use: employ only under supervision of an eye‑care professional experienced in paediatric ophthalmology. Pregnancy and lactation: safety has not been established; weigh potential benefits against risks before prescribing. Store at room temperature: keep in original container, protect from light and moisture.

Oxybuprocaine Hydrochloride can interact with other ophthalmic or systemic agents; awareness of these interactions helps ensure safe use.

Major Interactions (Avoid): - Systemic local anesthetics: concurrent use may increase risk of systemic toxicity. - Cholinesterase inhibitors (e.g., physostigmine): may prolong ocular anesthetic effect.

Moderate Interactions (Monitor Closely): - Antibiotic eye drops (e.g., fluoroquinolones): may affect corneal healing when used together. - Anti‑inflammatory eye drops (steroids or NSAIDs): may mask signs of irritation. - Other topical anesthetics: avoid simultaneous use to prevent additive toxicity.