GNH USA

Europe — EMA

Novalgine I.M./I.V. (Metamizole Sodium Monohydrate)

GNH USA supplies Novalgine I.M./I.V. (Metamizole), a non‑opioid analgesic for pain, fever and post‑operative analgesia. Request a quote for global supply.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole, the active ingredient in Novalgine I.M./I.V., is a pyrazolone derivative presented as an injectable solution for intramuscular and intravenous use. It treats pain and fever in adult patients, providing rapid relief in acute settings.

GNH USA supplies Novalgine I.M./I.V. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metamizole Sodium Monohydrate used for?

Metamizole is employed for analgesic and antipyretic management in conditions where inflammation‑mediated pain or fever is present.

- Pain: provides rapid relief of moderate to severe acute pain. - Fever: reduces elevated body temperature in febrile states. - Post‑operative analgesia: supports pain control after surgical procedures. - Acute musculoskeletal pain: offers effective analgesia for injuries and strain.

What are the side effects of Metamizole Sodium Monohydrate?

Adverse reactions may occur with Metamizole use.

Common Side Effects: - Injection site pain: mild discomfort at the site of administration. - Nausea: transient upset stomach. - Dizziness: occasional light‑headedness. - Flushing: brief skin reddening.

Serious or Rare Side Effects: - Agranulocytosis: severe reduction of white blood cells. - Anaphylaxis: life‑threatening allergic reaction. - Stevens‑Johnson syndrome: severe skin and mucous membrane disorder. - Hepatic failure: marked liver dysfunction.

What precautions apply to Metamizole Sodium Monohydrate?

Careful assessment and monitoring are required when using Metamizole.

- Assess renal function: adjust use in severe renal impairment. - Monitor blood counts: risk of agranulocytosis warrants periodic CBC. - Avoid in known hypersensitivity to pyrazolones. - Use cautiously in patients with cardiovascular disease due to hypotension risk. - Store at ambient temperature: keep in original container, protect from light and moisture.

What does Metamizole Sodium Monohydrate interact with?

Metamizole can interact with several drug classes; awareness of interaction severity helps guide safe use.

Major Interactions (Avoid): - Concurrent myelosuppressive agents: increased risk of agranulocytosis. - Other NSAIDs: additive gastrointestinal and renal toxicity. - ACE inhibitors: may enhance hypotensive effect.

Moderate Interactions (Monitor Closely): - Anticoagulants (e.g., warfarin): may increase bleeding tendency. - Diuretics: potential for reduced renal perfusion. - Lithium: may raise lithium serum concentrations.

Frequently asked questions

What conditions is Novalgine I.M./I.V. used for?+
Novalgine I.M./I.V. contains metamizole sodium monohydrate and is indicated for the treatment of moderate to severe acute pain, reduction of fever, and as part of post‑operative analgesic regimens in adult patients. It is administered by intramuscular or intravenous injection under medical supervision.
How does metamizole work to relieve pain and fever?+
Metamizole works by inhibiting cyclooxygenase enzymes, which decreases the production of prostaglandins that sensitize nerve endings and raise body temperature. It may also modulate endogenous opioid pathways, enhancing analgesic effects without directly activating opioid receptors.
What is the usual dose of Novalgine I.M./I.V.?+
The specific dose of Novalgine I.M./I.V. is determined by the prescribing clinician based on the patient’s condition, weight, renal function, and response to therapy. Healthcare professionals follow local guidelines and adjust the regimen as needed.
Is Novalgine I.M./I.V. safe during pregnancy or breastfeeding?+
Safety data for metamizole in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Clinicians should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing patients.
How do I order Novalgine I.M./I.V. from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.
How does Novalgine compare with other non‑opioid analgesics?+
Compared with traditional NSAIDs, metamizole offers potent analgesic and antipyretic effects with a lower incidence of gastrointestinal irritation but carries a unique risk of agranulocytosis. Selection depends on the clinical scenario, patient risk factors, and the therapeutic profile required by the prescriber.
What are the storage and handling requirements for Novalgine I.M./I.V.?+
Novalgine I.M./I.V. should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect from moisture and light. The solution must be inspected for particulate matter before administration and used within the expiry date.
How is Novalgine I.M./I.V. administered?+
The product is supplied as a sterile injectable solution for intramuscular or intravenous injection. Administration is performed by qualified healthcare personnel using aseptic technique, with dosage and rate of infusion determined by the treating physician.
What are the most serious risks associated with Novalgine I.M./I.V.?+
The most serious risks include agranulocytosis, which can lead to severe infections, and rare hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Prompt monitoring of blood counts and immediate medical attention for any signs of severe allergic reaction are essential.
Who should not use Novalgine I.M./I.V.?+
Novalgine I.M./I.V. is contraindicated in patients with known hypersensitivity to metamizole or other pyrazolones, in individuals with a history of agranulocytosis, and in those with severe hepatic or renal impairment where the risk outweighs benefit. Clinical judgment is required for all other cases.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Intramuscular Use , Intravenous Use
Manufacturer
Opella Healthcare Belgium (Handelsnaam Sanofi Belgium)
Origin
EU

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