GNH USA

Europe — EMA

Novalgine I.M./I.V. (Metamizole Sodium Monohydrate)

GNH USA supplies Novalgine I.M./I.V. (Metamizole sodium monohydrate), a pyrazolone analgesic for pain relief and fever reduction.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole sodium monohydrate, the active ingredient in Novalgine I.M./I.V., is a pyrazolone analgesic presented as an injectable solution for intramuscular and intravenous use. It provides pain relief and fever reduction in adult patients.

GNH USA supplies Novalgine I.M./I.V. as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and procurement agencies worldwide. The company follows EU GMP standards and provides full regulatory documentation for global distribution.

What is Metamizole Sodium Monohydrate used for?

Novalgine (metamizole sodium monohydrate) is used in the management of acute pain and fever, acting as an analgesic and antipyretic.

- Postoperative pain: provides effective analgesia after surgical procedures. - Acute musculoskeletal pain: reduces pain intensity in injuries or strains. - Fever: lowers elevated body temperature in adults. - Renal colic: alleviates severe flank pain associated with kidney stones. - Cancer‑related breakthrough pain: offers supplemental analgesia for uncontrolled pain episodes.

What are the side effects of Metamizole Sodium Monohydrate?

Novalgine may cause a range of adverse reactions, from mild to severe. Patients should be monitored for any unexpected symptoms during therapy.

Common Side Effects: - Injection site pain - Nausea - Vomiting - Transient hypotension

Serious or Rare Side Effects: - Agranulocytosis (dangerously low white‑blood‑cell count) - Severe skin reactions such as Stevens‑Johnson syndrome - Anaphylactic shock - Other blood dyscrasias

What precautions apply to Metamizole Sodium Monohydrate?

Before using Novalgine, clinicians should consider several safety factors to minimize risk.

- Renal impairment: monitor kidney function and adjust use accordingly. - Hepatic disease: use with caution in patients with liver dysfunction. - History of blood disorders: avoid in individuals with prior agranulocytosis or severe leukopenia. - Concurrent use of other pyrazolones: contraindicated due to additive toxicity. - Pregnancy and lactation: safety not established; avoid unless clearly needed. - Store at ambient temperature: keep in original container, protect from light and moisture.

What does Metamizole Sodium Monohydrate interact with?

Novalgine can interact with other medicines, requiring attention to avoid harmful effects.

Major Interactions (Avoid): - Concurrent use with other myelosuppressive agents: increased risk of severe neutropenia. - Combination with sulfonamides: heightened chance of blood dyscrasias.

Moderate Interactions (Monitor Closely): - Co‑administration with anticoagulants: may enhance bleeding tendency. - Use with NSAIDs: additive gastrointestinal irritation. - Interaction with ACE inhibitors: possible reduction in antihypertensive effect.

Frequently asked questions

What is Novalgine I.M./I.V. used for?+
Novalgine I.M./I.V. contains metamizole sodium monohydrate and is indicated for the relief of moderate to severe pain and for the reduction of fever in adult patients, particularly in postoperative, acute musculoskeletal, and febrile settings.
How does metamizole sodium monohydrate work?+
Metamizole works by inhibiting cyclooxygenase enzymes, which reduces the production of prostaglandins that mediate pain and fever. It also has central nervous system effects that contribute to its analgesic and antipyretic properties, although the exact mechanism is not fully defined.
What is the usual dose of Novalgine I.M./I.V.?+
The appropriate dose of Novalgine I.M./I.V. is determined by the prescribing clinician based on the patient’s condition, weight, and clinical response. Dosage regimens are individualized and should follow local prescribing guidelines.
Is Novalgine safe during pregnancy or breastfeeding?+
Safety data for metamizole in pregnancy and lactation are limited. It is generally avoided unless the potential benefit justifies the risk. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.
How do I order Novalgine I.M./I.V. from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.
How does Novalgine compare with other analgesics?+
Novalgine (metamizole) belongs to the pyrazolone class, offering strong analgesic and antipyretic effects similar to non‑opioid analgesics but with a distinct safety profile. Compared with NSAIDs, it has less gastrointestinal irritation but carries a risk of blood dyscrasias such as agranulocytosis.
What are the storage and handling requirements for Novalgine I.M./I.V.?+
Novalgine should be stored at ambient temperature, protected from light and moisture, and kept in its original packaging. Do not freeze the solution. Follow the label instructions for handling to maintain sterility before administration.
How is Novalgine I.M./I.V. administered?+
Novalgine is supplied as a sterile injectable solution for intramuscular or intravenous injection. Administration should be performed by qualified healthcare personnel using aseptic technique, with the dose prepared according to the prescribing information.
What are the most serious risks associated with Novalgine?+
The most serious risks include agranulocytosis, severe skin reactions such as Stevens‑Johnson syndrome, and anaphylaxis. Patients should be monitored for signs of infection, rash, or allergic reactions, and immediate medical attention is required if these occur.
Who should not use Novalgine I.M./I.V.?+
Novalgine is contraindicated in patients with known hypersensitivity to metamizole or other pyrazolones, those with a history of agranulocytosis, and individuals receiving other myelosuppressive drugs. Caution is also advised in patients with severe renal or hepatic impairment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Intramuscular Use , Intravenous Use
Manufacturer
Opella Healthcare Belgium (Handelsnaam Sanofi Belgium)
Origin
EU

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