GNH USA

Europe — EMA

Novalgina (Metamizole Sodium)

GNH USA supplies Novalgina (Metamizole Sodium), a pyrazolone derivative analgesic and antipyretic for pain and fever. Request a quote for global supply.

Metamizole Sodium

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What is Metamizole Sodium?

Metamizole sodium, the active ingredient in Novalgina, is a pyrazolone derivative presented as an oral dosage form for oral use. It provides analgesic and antipyretic effects for the treatment of pain and fever in adult patients, and is commonly prescribed when rapid relief of moderate to severe pain or high temperature is required under medical supervision.

GNH USA supplies Novalgina as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metamizole Sodium used for?

Novalgina (metamizole sodium) is employed to manage conditions that involve pain pathways or elevated body temperature.

- Pain: Provides analgesic relief for moderate to severe acute pain. - Fever: Reduces high fever when other antipyretics are insufficient. - Postoperative pain: Controls pain following surgical procedures.

What are the side effects of Metamizole Sodium?

Metamizole sodium may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Vomiting: occasional emesis. - Dizziness: transient light‑headedness. - Hypotension: temporary drop in blood pressure. - Skin rash: mild erythema or itching. - Elevated liver enzymes: transient increase in hepatic markers.

Serious or Rare Side Effects: - Agranulocytosis: severe reduction in white blood cells. - Stevens‑Johnson syndrome: life‑threatening skin reaction. - Anaphylaxis: acute allergic response with airway compromise. - Hepatic failure: rare but serious liver injury.

What precautions apply to Metamizole Sodium?

When prescribing Novalgina, clinicians should observe several safety measures to minimize risk.

- Monitor blood counts: perform regular complete blood count to detect agranulocytosis early. - Assess renal function: adjust use in patients with severe renal impairment. - Evaluate hepatic status: exercise caution in existing liver disease. - Avoid in known hypersensitivity: discontinue if allergic reactions occur. - Use with caution in the elderly: increased susceptibility to hypotension and dizziness. - Store at ambient temperature: keep below 25 °C in the original packaging, protect from moisture.

What does Metamizole Sodium interact with?

Metamizole sodium can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other myelosuppressive agents: heightened risk of agranulocytosis. - Concurrent NSAIDs: additive gastrointestinal and hematologic toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors or diuretics: may enhance hypotensive effect. - Lithium: possible increase in lithium serum levels. - CYP450 substrates: potential alteration of metabolism for drugs processed by the same enzymes.

Frequently asked questions

What is Novalgina used for?+
Novalgina contains metamizole sodium and is used as an analgesic and antipyretic. It provides relief from moderate to severe pain and helps reduce high fever when other treatments are insufficient. The drug is prescribed by healthcare professionals for conditions such as acute pain, postoperative discomfort, and febrile states.
How does metamizole sodium work?+
Metamizole sodium works by inhibiting cyclooxygenase enzymes, which lowers prostaglandin production in both peripheral tissues and the central nervous system. This reduction dampens pain signaling pathways and resets the hypothalamic temperature set‑point, resulting in analgesic and antipyretic effects. It also influences central pain modulation mechanisms.
What is the usual dose of Novalgina?+
The appropriate dose of Novalgina is determined by the prescribing clinician based on the individual patient's condition, age, weight, and response to therapy. Healthcare providers consider factors such as the severity of pain or fever and any relevant comorbidities before establishing a dosing regimen.
Is Novalgina safe during pregnancy or breastfeeding?+
The safety of metamizole sodium in pregnancy and lactation has not been definitively established. It is generally classified as a category where use is avoided unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant or breastfeeding should discuss alternatives with their healthcare provider.
How do I order Novalgina from GNH USA?+
To order Novalgina, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies, and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements), and assist with import documentation.
How does Novalgina compare with other analgesics?+
Novalgina (metamizole sodium) belongs to the pyrazolone class, offering analgesic and antipyretic effects similar to NSAIDs but with a distinct mechanism that may provide rapid pain relief. Unlike opioids, it does not act on opioid receptors, reducing the risk of dependence. However, it carries a unique risk of agranulocytosis, which is less common with many NSAIDs.
How should Novalgina be stored?+
Novalgina should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in their original packaging to protect them from moisture and light. Do not store in areas with high humidity or extreme heat, and keep the product out of reach of children.
How is Novalgina administered?+
Novalgina is administered orally. The tablet should be swallowed whole with a glass of water, preferably after a meal to reduce gastrointestinal discomfort. The exact administration schedule and any required monitoring are determined by the prescribing clinician.
What are the most serious risks to watch for with Novalgina?+
The most serious adverse reactions associated with Novalgina include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe skin reactions such as Stevens‑Johnson syndrome. Anaphylactic shock, though rare, can also occur. Patients should be instructed to seek immediate medical attention if they develop signs of infection, unexplained fever, rash, or breathing difficulties.
Who should not use Novalgina?+
Novalgina should be avoided in individuals with known hypersensitivity to metamizole or other pyrazolones, patients with pre‑existing severe blood dyscrasias, and those who have experienced agranulocytosis with any medication. Caution is also advised for patients with severe liver or kidney impairment, and it is generally contraindicated during pregnancy unless no safer alternative exists.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium
Route
Oral Use
Manufacturer
Opella Healthcare Italy S.R.L.
Origin
EU

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