GNH USA

Europe — EMA

Novalgin (Metamizole Sodium Monohydrate)

GNH USA supplies Novalgin (Metamizole), a pyrazolone analgesic for pain, fever and visceral colic. Request a quote for supply to hospitals and pharmacies.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole, the active ingredient in Novalgin, is a pyrazolone analgesic presented as an oral formulation for oral use. It provides relief from acute pain, fever, postoperative discomfort and visceral colic, primarily in adult patients. The drug works by inhibiting cyclooxygenase enzymes, reducing prostaglandin synthesis, and modulating central pain pathways, which contributes to its antipyretic and analgesic effects.

GNH USA supplies Novalgin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metamizole Sodium Monohydrate used for?

Novalgin (metamizole) is used to manage pain and fever across several clinical situations.

- Acute pain: Reduces intensity of sudden, severe pain episodes. - Fever: Lowers elevated body temperature in febrile states. - Post‑operative pain: Provides analgesia after surgical procedures. - Colic and visceral pain: Alleviates spasm‑related abdominal discomfort.

What are the side effects of Metamizole Sodium Monohydrate?

Metamizole may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: Mild gastrointestinal upset. - Vomiting: Occasional emesis. - Dizziness: Transient light‑headedness. - Skin rash: Mild erythematous eruptions. - Hypotension: Temporary drop in blood pressure.

Serious or Rare Side Effects: - Agranulocytosis: Severe reduction in white blood cells. - Anaphylaxis: Life‑threatening allergic reaction. - Stevens‑Johnson syndrome: Severe skin and mucous membrane disorder. - Hepatotoxicity: Liver enzyme elevations or injury.

What precautions apply to Metamizole Sodium Monohydrate?

When prescribing or dispensing Novalgin, several safety considerations should be observed. - Indication assessment: Confirm that pain or fever warrants use of a pyrazolone analgesic. - Hematologic monitoring: Periodically check complete blood count, especially for agranulocytosis risk. - Renal function: Evaluate kidney status in patients with pre‑existing impairment. - Concomitant drugs: Review for potential interactions with anticoagulants or immunosuppressants. - Pregnancy and lactation: Use only if benefits outweigh potential risks, after professional evaluation. - Store at ambient temperature: Keep below 25 °C in the original packaging, protect from moisture and direct sunlight.

What does Metamizole Sodium Monohydrate interact with?

Metamizole can affect the activity of several other medicines; awareness of these interactions helps prevent adverse outcomes.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): Increased bleeding risk. - Immunosuppressants (e.g., cyclosporine): Enhanced myelosuppression.

Moderate Interactions (Monitor Closely): - ACE inhibitors: May potentiate hypotensive effects. - Diuretics: Possible additive blood pressure lowering. - Lithium: Risk of increased serum lithium levels. - Other NSAIDs: Combined gastrointestinal toxicity.

Frequently asked questions

What is Novalgin used for?+
Novalgin, containing the active ingredient metamizole, is indicated for the relief of acute pain, reduction of fever, management of postoperative discomfort, and treatment of colic or visceral pain. It is commonly prescribed for adult patients when rapid analgesic and antipyretic effects are required.
How does Metamizole work?+
Metamizole works by inhibiting cyclooxygenase enzymes, which lowers prostaglandin production involved in pain and fever pathways. It also modulates central nervous system pain transmission, providing both peripheral and central analgesic effects that help control various types of acute and visceral pain.
What determines the usual dose of Novalgin?+
The appropriate dose of Novalgin is determined by the prescribing clinician based on the patient’s age, weight, severity of pain or fever, and overall health status. Dosage regimens are individualized and should follow the prescriber’s instructions and local regulatory guidelines.
Is Novalgin safe during pregnancy or breastfeeding?+
Safety of Novalgin in pregnancy or lactation has not been definitively established. It should only be used if the potential therapeutic benefit justifies the possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.
How do I order Novalgin from GNH USA?+
To order Novalgin, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Novalgin compare with other analgesics such as NSAIDs?+
Novalgin (metamizole) belongs to the pyrazolone class, offering analgesic and antipyretic effects similar to NSAIDs but with a distinct mechanism that includes central pain modulation. It may be preferred when NSAIDs are contraindicated, though it carries a unique risk profile, including rare blood‑cell disorders.
What are the recommended storage and handling conditions for Novalgin?+
Novalgin should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.
How is Novalgin administered to patients?+
Novalgin is administered orally, typically in tablet or liquid form, as directed by a healthcare professional. The medication should be taken with a full glass of water and may be taken with or without food, depending on the prescriber’s guidance.
What are the most serious risks associated with Novalgin use?+
The most serious risks include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored for signs of infection, skin changes, or breathing difficulties, and seek immediate medical attention if these occur.
Who should not use Novalgin?+
Novalgin should be avoided in individuals with known hypersensitivity to metamizole or other pyrazolones, patients with a history of agranulocytosis, severe liver or kidney impairment, and those taking medications that may interact dangerously, such as certain anticoagulants, without close medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Oral Use
Manufacturer
Opella Healthcare Slovakia S.R.O.
Origin
EU

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