GNH USA

Europe — EMA

Novalgin (Metamizole Sodium Monohydrate)

GNH USA supplies Novalgin (Metamizole Sodium), a non‑opioid analgesic for mild to moderate pain, postoperative pain and fever.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole Sodium, the active ingredient in Novalgin, is a pyrazolone non‑opioid analgesic presented as an oral tablet for systemic use. It treats mild to moderate pain, postoperative pain, colic and fever in adults.

GNH USA supplies Novalgin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metamizole Sodium Monohydrate used for?

Novalgin is used for pain and fever management across several clinical situations.

- Mild to moderate pain: provides analgesia for everyday pain conditions. - Post‑operative pain: helps control discomfort after surgical procedures. - Colic: relieves visceral pain associated with gastrointestinal spasm. - Fever: reduces elevated body temperature in febrile states.

What are the side effects of Metamizole Sodium Monohydrate?

Metamizole Sodium may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Vomiting: occasional emesis. - Dizziness: transient light‑headedness. - Headache: mild to moderate intensity. - Rash: skin irritation or erythema. - Hypotension: occasional drop in blood pressure.

Serious or Rare Side Effects: - Agranulocytosis: severe reduction in white blood cells. - Severe allergic reactions: including anaphylaxis. - Stevens‑Johnson syndrome: rare skin disorder. - Blood dyscrasias: abnormal blood cell counts. - Hepatic injury: liver function impairment. - Renal failure: acute kidney injury in susceptible patients.

What precautions apply to Metamizole Sodium Monohydrate?

When prescribing Metamizole Sodium, clinicians should consider several safety aspects.

- Renal impairment: use with caution and monitor kidney function. - Hepatic dysfunction: assess liver enzymes before initiation. - History of blood disorders: avoid in patients with prior agranulocytosis. - Concomitant pyrazolones: avoid combined use to reduce toxicity risk. - Pregnancy: limit to situations where benefits outweigh potential risks. - Store at ambient temperature: keep in the original pack, protect from moisture.

What does Metamizole Sodium Monohydrate interact with?

Metamizole Sodium can interact with other medicines, requiring attention to the level of risk.

Major Interactions (Avoid): - Sulfonamide antibiotics: increased risk of agranulocytosis. - Cytotoxic chemotherapy agents: heightened bone‑marrow suppression. - Anticoagulants (e.g., warfarin): potential for enhanced bleeding.

Moderate Interactions (Monitor Closely): - NSAIDs: additive gastrointestinal irritation. - ACE inhibitors: possible additive hypotensive effect. - Diuretics: monitor electrolytes and renal function.

Frequently asked questions

What conditions is Novalgin used to treat?+
Novalgin, containing Metamizole Sodium, is prescribed for mild to moderate pain, postoperative discomfort, colic associated with gastrointestinal spasm, and fever. It is used in adult patients when a non‑opioid analgesic is appropriate.
How does Metamizole Sodium work to relieve pain and fever?+
Metamizole Sodium blocks cyclooxygenase enzymes, lowering prostaglandin production, which reduces pain and fever. It also influences endogenous opioid pathways, enhancing analgesic effects, although the exact mechanisms are not completely understood.
What is the usual dose of Novalgin?+
The dosage of Novalgin is individualized by the prescribing clinician based on the patient’s condition, age, weight, and renal or hepatic function. The prescriber determines the appropriate strength, frequency, and duration of therapy.
Is Novalgin safe to use during pregnancy or breastfeeding?+
Safety data for Metamizole Sodium in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.
How do I order Novalgin from GNH USA?+
To request Novalgin, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.
How does Novalgin compare with other analgesics?+
Novalgin belongs to the pyrazolone class, offering non‑opioid analgesia similar to other agents like dipyrone. Compared with NSAIDs, it may have a lower risk of gastrointestinal ulceration but carries a distinct risk of agranulocytosis, requiring careful monitoring.
What are the storage requirements for Novalgin?+
Novalgin tablets should be stored at ambient temperature, below 25 °C, in their original packaging. Protect them from moisture and direct sunlight to maintain stability and potency.
How is Novalgin administered?+
Novalgin is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional.
What are the most serious risks associated with Novalgin?+
The most serious adverse reactions include agranulocytosis, severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome, and significant hepatic or renal injury. Prompt medical attention is required if any of these symptoms develop.
Who should not use Novalgin?+
Novalgin is contraindicated in patients with known hypersensitivity to Metamizole or other pyrazolones, those with a history of agranulocytosis, severe liver or kidney disease, and individuals for whom safer alternatives are available.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Oral Use
Manufacturer
A. Nattermann & Cie. Gmbh
Origin
EU

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