GNH USA

Europe — EMA

Novalgin (Metamizole Sodium Monohydrate)

GNH USA supplies Novalgin (Metamizole Sodium), a pyrazolone non‑opioid analgesic for acute and post‑operative pain, fever and visceral pain. Request a quote.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole Sodium, the active ingredient in Novalgin, is a pyrazolone non‑opioid analgesic presented as an injectable solution for intramuscular and intravenous use. It treats acute and postoperative pain, fever, and visceral colic in adult patients. GNH USA supplies Novalgin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

What is Metamizole Sodium Monohydrate used for?

Novalgin (metamizole sodium) acts on pain and fever pathways in various clinical settings.

Acute pain: provides rapid relief of severe short‑term pain. Post‑operative pain: reduces discomfort after surgical procedures. Fever: lowers elevated body temperature. Colic and visceral pain: alleviates spasm‑related abdominal discomfort.

What are the side effects of Metamizole Sodium Monohydrate?

Metamizole sodium may cause a range of adverse reactions.

Common Side Effects: - Injection site pain or erythema - Nausea or vomiting - Dizziness or light‑headedness - Transient hypotension - Mild skin rash - Headache

Serious or Rare Side Effects: - Agranulocytosis (dangerously low white blood cell count) - Anaphylactic shock - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Severe hypotension requiring intervention - Hepatic failure or elevated liver enzymes - Blood dyscrasias such as thrombocytopenia

What precautions apply to Metamizole Sodium Monohydrate?

Use of Novalgin requires careful clinical assessment and monitoring.

Assess renal and hepatic function before initiating therapy. Monitor complete blood counts regularly, especially for signs of agranulocytosis. Use with caution in patients with known hypersensitivity to pyrazolones. Avoid in individuals with a history of severe blood dyscrasias. Administer only under medical supervision and adjust dose as needed. Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

What does Metamizole Sodium Monohydrate interact with?

Metamizole sodium can interact with several medications, necessitating vigilance.

Major Interactions (Avoid): - Warfarin: increased risk of bleeding. - Cyclosporine: heightened nephrotoxicity. - Sulfonamides: additive risk of blood dyscrasias. - ACE inhibitors: potentiated hypotensive effect. - Lithium: possible alteration of serum levels.

Moderate Interactions (Monitor Closely): - NSAIDs: additive gastrointestinal irritation. - Antidepressants (SSRIs/SNRIs): potential for serotonin syndrome. - Diuretics: enhanced hypotensive response. - Anticonvulsants (e.g., phenytoin): possible pharmacokinetic changes. - Alcohol: increased sedation and dizziness.

Frequently asked questions

What is Novalgin used for?+
Novalgin contains metamizole sodium, which is prescribed to manage moderate to severe acute pain, postoperative pain, high fever, and visceral colic. It is typically used in hospital settings for patients requiring rapid analgesia and antipyretic effects.
How does metamizole sodium work?+
Metamizole sodium works by non‑selectively inhibiting cyclooxygenase enzymes, decreasing prostaglandin production. This reduces pain signaling and fever, while also providing a spasmolytic effect on smooth muscle, helping to relieve visceral pain.
What is the usual dose of Novalgin?+
The dose of Novalgin is determined by the prescribing clinician based on the patient’s condition, age, weight, and response. It is administered by intramuscular or intravenous injection under medical supervision.
Is Novalgin safe during pregnancy or breastfeeding?+
The safety of metamizole sodium in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and only under the guidance of a qualified healthcare professional.
How do I order Novalgin from GNH USA?+
To order Novalgin, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.
How does Novalgin compare with other analgesics?+
Novalgin (metamizole sodium) belongs to the pyrazolone class, offering strong analgesic and antipyretic effects with a spasmolytic component. Compared with NSAIDs, it has a lower risk of gastrointestinal irritation but carries a rare risk of agranulocytosis. It is distinct from opioid analgesics, which act on opioid receptors and have different side‑effect profiles.
What are the storage requirements for Novalgin?+
Novalgin should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly sealed to maintain sterility.
How is Novalgin administered?+
Novalgin is administered by a healthcare professional via intramuscular or intravenous injection. The route, injection site, and rate of administration are determined by the prescriber based on the clinical situation.
What are the most serious risks associated with Novalgin?+
The most serious risks include agranulocytosis, a severe reduction in white blood cells that can lead to life‑threatening infections, and rare allergic reactions such as anaphylaxis or severe skin disorders like Stevens‑Johnson syndrome. Immediate medical attention is required if these symptoms occur.
Who should not use Novalgin?+
Novalgin should not be used by patients with a known hypersensitivity to metamizole or other pyrazolones, those with a history of agranulocytosis or severe blood dyscrasias, and it is contraindicated in individuals for whom the risk outweighs the benefit as assessed by a qualified clinician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Intramuscular Use , Intravenous Use
Manufacturer
Opella Healthcare Slovakia S.R.O.
Origin
EU

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