GNH USA

Europe — EMA

Novalgin (Metamizole Sodium Monohydrate)

GNH USA supplies Novalgin (metamizole sodium), an analgesic and antipyretic for severe pain, fever and post‑surgical pain. Request a quote for supply.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole sodium, the active ingredient in Novalgin, is a pyrazolone presented as an injectable solution for intramuscular or intravenous use. It is employed to manage severe pain, high fever, postoperative pain and colic in adult patients. GNH USA supplies Novalgin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metamizole Sodium Monohydrate used for?

Novalgin (metamizole sodium) is used for managing severe pain and high fever across several clinical situations.

Severe pain: provides rapid analgesia for acute, intense pain. Fever: lowers elevated body temperature in febrile patients. Postoperative pain: controls pain following surgical procedures. Colic: alleviates visceral pain associated with colic episodes.

What are the side effects of Metamizole Sodium Monohydrate?

Novalgin may cause a range of adverse reactions, which vary in frequency and severity.

Common Side Effects: - Injection site pain or irritation. - Mild hypotension or dizziness. - Nausea or vomiting. - Transient headache. - Mild skin rash. - Elevated liver enzymes.

Serious or Rare Side Effects: - Agranulocytosis, a potentially life‑threatening drop in white blood cells. - Severe cutaneous reactions such as Stevens‑Johnson syndrome. - Anaphylactic or anaphylactoid shock. - Hemolytic anemia. - Acute renal failure. - Severe hypotensive episodes.

What precautions apply to Metamizole Sodium Monohydrate?

When using Novalgin, several safety considerations should be observed.

Renal function: monitor patients with impaired kidney function. Hepatic function: use cautiously in those with liver disease. Blood disorders: avoid in individuals with a history of agranulocytosis. Drug interactions: review concomitant medications, especially other NSAIDs or anticoagulants. Pregnancy and lactation: safety not established; avoid unless clearly needed. Store at ambient temperature: keep in the original container, protect from light and moisture.

What does Metamizole Sodium Monohydrate interact with?

Novalgin can interact with various medicines; awareness of the interaction level helps guide clinical decisions.

Major Interactions (Avoid): - Concurrent NSAIDs or other COX inhibitors: increased risk of toxicity. - Anticoagulants (e.g., warfarin): heightened bleeding tendency. - Immunosuppressants such as methotrexate: potential for enhanced myelosuppression.

Moderate Interactions (Monitor Closely): - ACE inhibitors or diuretics: may affect renal function. - Lithium: possible elevation of lithium serum levels. - Systemic corticosteroids: additive gastrointestinal risk.

Frequently asked questions

What is Novalgin used for?+
Novalgin is indicated for the treatment of severe acute pain, high fever, postoperative pain and visceral pain such as colic. It is administered by injection and is typically used in hospital or clinical settings where rapid analgesia or antipyresis is required.
How does metamizole sodium work?+
Metamizole sodium provides analgesic and antipyretic effects by non‑selectively inhibiting cyclooxygenase enzymes, which lowers prostaglandin production. The reduction in prostaglandins diminishes peripheral pain signalling, while central mechanisms and smooth‑muscle spasmolysis contribute to its overall therapeutic action.
What is the usual dose of Novalgin?+
The dose of Novalgin is determined by the prescribing clinician based on the patient’s condition, severity of pain or fever, and individual health factors. Dosage adjustments may be required for renal or hepatic impairment, and the medication should be administered only under medical supervision.
Is Novalgin safe during pregnancy or breastfeeding?+
Safety data for metamizole sodium in pregnancy and lactation are limited, and the drug is generally not recommended unless the potential benefit outweighs the risk. Healthcare providers should evaluate each case individually and consider alternative therapies when possible.
How do I order Novalgin from GNH USA?+
To order Novalgin, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.
How does Novalgin compare with other analgesics like paracetamol or NSAIDs?+
Novalgin belongs to the pyrazolone class and offers rapid, potent analgesia and antipyresis, often stronger than paracetamol and comparable to strong NSAIDs. Unlike many NSAIDs, it has a distinct risk profile, notably the potential for agranulocytosis, which requires careful monitoring.
How should Novalgin be stored and handled?+
Novalgin should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the solution from light, moisture and extreme temperatures. Before administration, inspect the vial for particulate matter and ensure the solution is clear.
How is Novalgin administered?+
Novalgin is supplied as an injectable solution and can be given either intramuscularly or intravenously. Administration is performed by qualified healthcare personnel, following aseptic technique and appropriate dosing guidelines set by the prescriber.
What are the most serious risks to watch for with Novalgin?+
The most critical safety concerns include agranulocytosis, severe skin reactions such as Stevens‑Johnson syndrome, anaphylaxis, and hemolytic anemia. Patients should be monitored for signs of infection, rash, breathing difficulty or sudden drop in blood pressure, and the drug should be discontinued immediately if these occur.
Who should not use Novalgin?+
Novalgin is contraindicated in individuals with known hypersensitivity to metamizole or other pyrazolones, a history of agranulocytosis, severe liver or kidney disease, and in patients where the risk of severe adverse reactions outweighs the therapeutic benefit.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Intramuscular Use , Intravenous Use
Manufacturer
A. Nattermann & Cie. Gmbh
Origin
EU

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