GNH USA

Europe — EMA

Novalgin (Metamizole Sodium Monohydrate)

GNH USA supplies Novalgin (Metamizole Sodium), a non‑opioid analgesic for acute pain, postoperative pain and fever. Request a quote for global supply.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole sodium, the active ingredient in Novalgin, is a non‑opioid analgesic (pyrazolone derivative) presented as an injectable solution for intramuscular or intravenous use. It provides rapid relief of acute pain, postoperative discomfort, fever, and visceral colic in adult patients.

GNH USA supplies Novalgin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company ensures quality compliance with EU standards and offers reliable logistics for global distribution through a network of certified partners.

What is Metamizole Sodium Monohydrate used for?

Novalgin (metamizole sodium) is employed to manage pain and fever by inhibiting prostaglandin synthesis.

- Acute pain: delivers rapid analgesia for sudden severe pain. - Post‑operative pain: reduces discomfort after surgical procedures. - Fever: lowers elevated body temperature in febrile states. - Visceral colic: alleviates spasm‑related abdominal pain.

What are the side effects of Metamizole Sodium Monohydrate?

Metamizole sodium may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Injection site pain: mild discomfort at the administration site. - Nausea: transient feeling of queasiness. - Dizziness: occasional light‑headedness. - Hypotension: temporary drop in blood pressure. - Rash: mild skin erythema.

Serious or Rare Side Effects: - Agranulocytosis: severe reduction of white blood cells, potentially life‑threatening. - Anaphylactic reaction: rapid onset of allergic symptoms requiring emergency care. - Stevens‑Johnson syndrome: rare severe skin and mucous membrane disorder.

What precautions apply to Metamizole Sodium Monohydrate?

When using Novalgin, several safety considerations should be observed to minimize risk. - Renal impairment: assess kidney function and adjust use as needed. - Hepatic dysfunction: exercise caution in patients with liver disease. - History of agranulocytosis: avoid use due to risk of recurrence. - Concurrent myelosuppressive therapy: monitor blood counts closely. - Pregnancy and lactation: prescribe only if benefits outweigh potential risks. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Metamizole Sodium Monohydrate interact with?

Metamizole sodium can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid): - Cytotoxic chemotherapy agents: additive bone‑marrow suppression may occur. - Sulfonamide antibiotics: combined risk of agranulocytosis. - Anticoagulants (e.g., warfarin): potential enhancement of bleeding tendency.

Moderate Interactions (Monitor Closely): - NSAIDs: may increase gastrointestinal irritation. - Corticosteroids: heightened risk of infection and delayed wound healing. - Alcohol: can potentiate dizziness and hypotension.

Frequently asked questions

What is Novalgin used for?+
Novalgin, containing metamizole sodium, is indicated for the short‑term management of moderate to severe acute pain, postoperative pain, fever, and visceral colic. It is commonly employed in hospital settings for patients requiring rapid analgesia or antipyretic effect when other treatments are unsuitable.
How does metamizole sodium work?+
Metamizole sodium works mainly by inhibiting cyclooxygenase enzymes, which reduces the synthesis of prostaglandins involved in pain perception and temperature regulation. Additionally, it has spasmolytic properties that relax smooth muscle, helping to relieve visceral colic and related discomfort.
What is the usual dose of Novalgin?+
The appropriate dose of Novalgin is determined by the prescribing clinician based on the patient’s condition, age, weight, and clinical response. Dosage regimens may differ for intramuscular versus intravenous administration, and the prescriber will tailor the regimen to each individual case.
Is Novalgin safe during pregnancy or breastfeeding?+
The safety of metamizole sodium in pregnancy and lactation has not been definitively established. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.
How do I order Novalgin from GNH USA?+
To order Novalgin, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.
How does Novalgin compare with other analgesics?+
Novalgin offers a non‑opioid alternative to NSAIDs and opioid analgesics. Compared with NSAIDs, it has a lower risk of gastrointestinal irritation but carries a rare risk of agranulocytosis. Unlike opioids, it does not cause respiratory depression, making it useful when opioid‑related side effects are a concern.
How should Novalgin be stored and handled?+
Novalgin injectable solution should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Prior to administration, allow the product to reach room temperature if required, and inspect for particulate matter or discoloration before use.
How is Novalgin administered?+
Novalgin is administered by a healthcare professional either intramuscularly or intravenously. The solution is typically drawn into a sterile syringe, and the injection site is prepared according to aseptic technique. Dosage and rate of infusion are determined by the prescriber based on the clinical situation.
What are the most serious risks to watch for with Novalgin?+
The most serious adverse reactions associated with Novalgin are agranulocytosis, a potentially fatal drop in white blood cells, and severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored for signs of infection, fever, or skin changes, and treatment should be stopped immediately if these occur.
Who should not use Novalgin?+
Novalgin is contraindicated in individuals with a known hypersensitivity to metamizole or any pyrazolone derivatives, in patients with a history of agranulocytosis, and in those receiving other myelosuppressive agents without close monitoring. Caution is also advised for patients with severe renal or hepatic impairment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Intramuscular Use , Intravenous Use
Manufacturer
Opella Healthcare Austria Gmbh
Origin
EU

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