GNH USA

Europe — EMA

Novain (Oxybuprocaine Hydrochloride)

GNH USA supplies Novain (Oxybuprocaine Hydrochloride), a local anesthetic for ocular surface anesthesia in eye exams and procedures.

Oxybuprocaine Hydrochloride

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What is Oxybuprocaine Hydrochloride?

Oxybuprocaine Hydrochloride, the active ingredient in Novain, is a local anesthetic presented as a sterile ophthalmic solution for ocular use. It provides rapid, temporary numbing of the eye surface for diagnostic examinations, minor surgical procedures, and laser treatments. It is indicated for short‑term anesthesia during slit‑lamp examinations, foreign‑body removal, and corneal laser procedures, with an onset of action within seconds and a duration of a few minutes.

GNH USA supplies Novain as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing, regulatory support and global logistics for consistent product availability.

What is Oxybuprocaine Hydrochloride used for?

Novain, an ophthalmic local anesthetic, is used to achieve temporary loss of sensation on the ocular surface for various eye care procedures.

Diagnostic eye examinations: provides rapid surface anesthesia for slit‑lamp and fundus evaluations Minor ocular surgeries: facilitates corneal foreign‑body removal and minor surgical interventions Laser eye procedures: numbs the cornea during laser photocoagulation or refractive treatments

What are the side effects of Oxybuprocaine Hydrochloride?

Novain may cause a range of ocular reactions, from mild irritation to rare severe events.

Common Side Effects: - Transient burning or stinging sensation upon instillation - Temporary redness or tearing of the eye - Mild blurred vision lasting a few minutes - Mild allergic conjunctivitis with itching

Serious or Rare Side Effects: - Corneal epithelial defect or ulceration - Severe allergic reaction, including anaphylaxis - Persistent loss of corneal sensation leading to infection - Intra‑ocular pressure elevation - Systemic toxicity in case of excessive exposure

What precautions apply to Oxybuprocaine Hydrochloride?

Before using Novain, consider the following safety measures.

Allergy assessment: avoid use in patients with known hypersensitivity to oxybuprocaine or related anesthetics Contact lens use: remove lenses prior to administration to prevent drug retention Duration of use: limit to single application or as directed to reduce risk of corneal toxicity Pediatric use: administer only under professional supervision and according to clinical judgment Pregnancy and lactation: safety not established; use only if benefit outweighs potential risk Store at room temperature: keep in original container, protect from light and moisture

What does Oxybuprocaine Hydrochloride interact with?

Novain can interact with other ophthalmic agents, requiring caution.

Major Interactions (Avoid): - Concurrent use with other topical ocular anesthetics: may increase corneal toxicity risk - Systemic aminoglycoside antibiotics: potential additive neurotoxicity (theoretical)

Moderate Interactions (Monitor Closely): - Combination with ocular anti‑inflammatory drops: monitor for delayed corneal healing - Use with beta‑blocker eye drops: observe for possible intra‑ocular pressure changes - Preservative‑containing eye solutions: may heighten ocular irritation

Frequently asked questions

What is Novain used for?+
Novain is a sterile ophthalmic solution containing Oxybuprocaine Hydrochloride, used to provide rapid, temporary anesthesia of the ocular surface. It is employed during diagnostic eye examinations, minor ocular procedures, and laser treatments to reduce discomfort and facilitate precise work. The anesthetic effect typically begins within seconds and lasts for a few minutes, allowing clinicians to perform interventions without pain.
How does Oxybuprocaine Hydrochloride work?+
Oxybuprocaine Hydrochloride acts by reversibly blocking voltage‑gated sodium channels in the membranes of peripheral nerve fibers in the cornea and conjunctiva. This inhibition prevents the initiation and propagation of nerve impulses, resulting in loss of sensation in the treated area. The blockade is localized and temporary, allowing normal nerve function to return shortly after the drug is cleared from the ocular surface.
What is the usual dose of Novain?+
The specific dose and frequency of Novain are determined by the prescribing eye care professional based on the procedure and patient factors. Typically, a single drop is applied to the conjunctival sac, and additional drops may be used if required, following the clinician’s instructions. Patients should not self‑administer or alter the dosing regimen without medical guidance.
Is Novain safe in pregnancy or breastfeeding?+
Safety data for Oxybuprocaine Hydrochloride in pregnant or lactating women are limited, and the product is not classified in a specific pregnancy category. Consequently, Novain should be used during pregnancy or breastfeeding only if the potential benefit justifies any potential risk to the fetus or infant, and under the direction of a qualified healthcare provider.
How do I order Novain from GNH USA?+
To request Novain, visit the product page on gnh-usa.com, enter the required quantity, and submit the enquiry form. GNH USA’s procurement team will contact the buyer to verify institutional or trade credentials, then provide pricing, availability, shipping details (including any temperature control if needed), and assist with the necessary import documentation for international delivery.
How does Novain compare with other ophthalmic anesthetics?+
Novain (Oxybuprocaine Hydrochloride) is a short‑acting ester‑type local anesthetic, similar in onset to proparacaine but with a slightly longer duration of action. Compared with lidocaine, it provides more rapid corneal anesthesia and less stinging on instillation. Choice of agent depends on the specific procedure, clinician preference, and patient tolerance, as each anesthetic has a distinct pharmacokinetic profile and side‑effect spectrum.
How should Novain be stored and handled?+
Novain should be stored at controlled room temperature, preferably below 25 °C, in its original sealed container. The product must be protected from light and moisture, and any opened vial should be used within the time frame specified by the manufacturer, typically a few hours, to maintain sterility and potency. Do not freeze the solution, and keep it out of reach of children.
How is Novain administered?+
Novain is administered as a sterile ophthalmic drop. The patient or clinician places a single drop onto the conjunctival sac of the eye to be anesthetized, ensuring the eyelids are gently closed for a few seconds to allow even distribution. The onset of anesthesia occurs within seconds, and the effect lasts for a short period, sufficient for diagnostic or minor therapeutic procedures. No systemic administration is required.
What are the most serious risks associated with Novain?+
Although rare, serious adverse events can include corneal epithelial defects, ulceration, severe allergic reactions such as anaphylaxis, and persistent loss of corneal sensation leading to infection. Systemic toxicity is uncommon but may occur with excessive dosing or accidental ingestion. Patients should be monitored for signs of severe irritation, visual changes, or systemic symptoms, and the drug should be discontinued immediately if serious reactions are observed.
Who should not use Novain?+
Novain should be avoided in individuals with a known hypersensitivity to Oxybuprocaine, other ester‑type local anesthetics, or any component of the formulation. It is also contraindicated in patients with active corneal infections, severe ocular surface disease, or those who have recently undergone corneal surgery where epithelial healing is critical. Use in infants, young children, or pregnant women should only be considered when the benefit outweighs the risk and under professional supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Oxybuprocaine Hydrochloride
Route
Ocular Use
Manufacturer
Agepha Pharma S.R.O
Origin
EU

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