GNH USA

Europe — EMA

Novain (Oxybuprocaine Hydrochloride)

GNH USA supplies Novain (Oxybuprocaine Hydrochloride), an ophthalmic local anesthetic for eye exams, surgery and corneal abrasion pain relief.

Oxybuprocaine Hydrochloride

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What is Oxybuprocaine Hydrochloride?

Oxybuprocaine Hydrochloride, the active ingredient in Novain, is a local anesthetic presented as a sterile ophthalmic solution for ocular (topical) use. It provides rapid surface numbness for diagnostic examinations, minor surgical procedures, and relief of pain from corneal abrasions or foreign‑body removal in adult patients and children under supervision.

GNH USA supplies Novain as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides regulatory documentation for importers.

What is Oxybuprocaine Hydrochloride used for?

Novain (oxybuprocaine hydrochloride) is used as a topical ophthalmic anesthetic to temporarily block sensory nerves during eye procedures.

- Diagnostic ocular procedures: provides rapid surface anesthesia for slit‑lamp examinations and intraocular pressure measurements. - Minor ocular surgery: enables painless corneal suturing, laser photocoagulation, or foreign‑body extraction. - Corneal abrasion or foreign body removal: relieves acute pain and discomfort during debridement.

What are the side effects of Oxybuprocaine Hydrochloride?

Oxybuprocaine hydrochloride may cause transient ocular reactions, and rare severe events have been reported.

Common Side Effects: - Stinging or burning sensation upon instillation. - Transient blurred vision. - Conjunctival redness. - Mild tearing.

Serious or Rare Side Effects: - Corneal epithelial toxicity with prolonged exposure. - Severe allergic reaction, including anaphylaxis. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Persistent ocular inflammation that may threaten vision.

What precautions apply to Oxybuprocaine Hydrochloride?

When using Novain, clinicians should observe several safety measures to minimise ocular irritation and systemic risk. - Allergy assessment: avoid in patients with known hypersensitivity to ester‑type ophthalmic anesthetics. - Contact lens wearers: remove lenses before instillation to prevent drug accumulation. - Compromised corneal epithelium: use with caution in eyes with epithelial defects or infections. - Pregnancy and lactation: safety not established; prescribe only if benefit outweighs potential risk. - Store at room temperature: keep in original container, protect from light and moisture.

What does Oxybuprocaine Hydrochloride interact with?

Oxybuprocaine hydrochloride can interact with other ophthalmic agents, affecting ocular tolerance or systemic sodium channel activity.

Major Interactions (Avoid): - Concurrent use of other topical ocular anesthetics: may cause additive corneal toxicity. - Systemic administration of local anesthetics: increased risk of cumulative sodium channel blockade. - Preservative‑rich eye drops combined with oxybuprocaine: heightened irritation and epithelial damage.

Moderate Interactions (Monitor Closely): - Beta‑blocker eye drops: may increase ocular surface irritation. - Anticholinergic ophthalmic solutions: possible alteration of pupil response. - Preservative‑containing contact lens solutions: monitor for increased corneal sensitivity.

Frequently asked questions

What is Novain used for?+
Novain is a topical ophthalmic preparation containing oxybuprocaine hydrochloride. It is used to provide short‑lasting numbness of the cornea and conjunctiva during diagnostic eye examinations, minor ocular surgeries, and to relieve pain from corneal abrasions or foreign‑body removal.
How does oxybuprocaine hydrochloride work?+
Oxybuprocaine hydrochloride blocks voltage‑gated sodium channels on peripheral nerve endings in the eye. By preventing sodium influx, it stops the generation and propagation of nerve impulses, resulting in rapid, reversible loss of sensation on the ocular surface.
What determines the dose of Novain?+
The dose and frequency of Novain are determined by the prescribing clinician based on the specific procedure, patient age, and ocular condition. No fixed regimen is provided here; the prescriber will decide the appropriate amount and timing.
Is Novain safe in pregnancy or breastfeeding?+
Safety data for oxybuprocaine hydrochloride in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.
How do I order Novain from GNH USA?+
To order Novain, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Novain compare with the main alternative drug or class?+
Novain (oxybuprocaine) and other ester‑type ophthalmic anesthetics such as proparacaine share a similar rapid onset and short duration. Oxybuprocaine may have slightly lower corneal toxicity in short‑term use, but all agents require careful handling to avoid epithelial damage with prolonged exposure.
What are the storage and handling requirements for Novain?+
Novain should be stored at room temperature, ideally below 25 °C, in its original sealed container. Protect the solution from direct light and moisture, and keep it out of reach of children. Do not freeze or expose to extreme temperatures.
How is Novain administered?+
Novain is applied as one or more drops to the conjunctival sac of the eye. The prescriber determines the number of drops and timing relative to the procedure. The patient should keep the eyelids gently closed for a few seconds to allow even distribution.
What are the most serious risks associated with Novain?+
Serious risks, although rare, include corneal epithelial toxicity leading to ulceration, severe allergic reactions such as anaphylaxis, and systemic hypersensitivity syndromes like Stevens‑Johnson syndrome. Immediate medical attention is required if any signs of severe reaction appear.
Who should not use Novain?+
Novain should be avoided in individuals with a known hypersensitivity to oxybuprocaine, other ester‑type local anesthetics, or any component of the formulation. It is also contraindicated when used concurrently with other topical ocular anesthetics without medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Oxybuprocaine Hydrochloride
Route
Ocular Use
Manufacturer
Agepha Pharma S.R.O
Origin
EU

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