Notus Antitusivo (Dextromethorphan Hydrobromide)

Dextromethorphan Hydrobromide, the active ingredient in Notus Antitusivo, is a NMDA receptor antagonist / sigma-1 receptor agonist presented as an oral dosage form for oral use. It provides temporary relief of cough caused by minor throat and bronchial irritation in adults and adolescents.

GNH USA supplies Notus Antitusivo as a licensed, GDP‑compliant international pharmaceutical supplier serving pharmacies and clinics worldwide.

Dextromethorphan acts on the central cough reflex pathway to suppress coughing associated with irritation of the throat or bronchial passages.

- Minor throat irritation: provides temporary relief of cough. - Bronchial irritation: reduces cough frequency and intensity. - Upper respiratory tract infection: helps control cough symptoms.

Common Side Effects: - Drowsiness: mild sedation may occur. - Dizziness: transient light‑headedness reported. - Nausea: occasional upset stomach. - Dry mouth: reduced salivation. - Constipation: slowed gastrointestinal motility. - Mild gastrointestinal upset: occasional discomfort.

Serious or Rare Side Effects: - Allergic reactions: rash, itching, or angioedema. - Serotonin syndrome: risk when combined with serotonergic agents. - Respiratory depression: rare, especially with overdose. - Hallucinations or psychotic symptoms: uncommon CNS effects. - Seizures: very rare neurological events. - Severe skin reactions: such as Stevens‑Johnson syndrome.

Before using Notus Antitusivo, consider the following precautions. - Pregnancy: safety not established; avoid unless benefit outweighs risk. - Breastfeeding: unknown safety; assess potential infant exposure. - Age: not recommended for children under 4 years. - Drug interactions: avoid concomitant use with MAO inhibitors. - Medical conditions: use cautiously in patients with hepatic impairment. - Store at ambient temperature: keep in the original pack, protect from moisture and light.

Dextromethorphan may interact with several medicines; review the following.

Major Interactions (Avoid): - MAO inhibitors: risk of severe serotonin syndrome. - Selective serotonin reuptake inhibitors (SSRIs): increased serotonin toxicity. - Tricyclic antidepressants: heightened central nervous system effects.

Moderate Interactions (Monitor Closely):\n- Alcohol: additive CNS depression may increase drowsiness. - Opioids: potential for enhanced respiratory depression. - Antihistamines: may increase sedation and dizziness.