GNH USA

Europe — EMA

Notezine (Diethylcarbamazine Citrate)

GNH USA supplies Notezine (Diethylcarbamazine citrate), a antifilarial anthelmintic for lymphatic filariasis, loiasis and onchocerciasis.

Diethylcarbamazine Citrate

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What is Diethylcarbamazine Citrate?

Diethylcarbamazine citrate, the active ingredient in Notezine, is an anthelmintic presented as an oral dosage form for oral use. It is employed to treat infections caused by filarial parasites, primarily in endemic regions and in patients requiring antifilarial therapy. GNH USA supplies Notezine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Diethylcarbamazine Citrate used for?

Diethylcarbamazine citrate acts on filarial parasites and is indicated for several filariasis‑related conditions. - Lymphatic filariasis: reduces microfilarial load and helps prevent disease progression. - Loiasis: eliminates Loa loa microfilariae and alleviates ocular and subcutaneous manifestations. - Onchocerciasis: decreases microfilarial density, contributing to control of river blindness.

What are the side effects of Diethylcarbamazine Citrate?

Adverse reactions may occur with diethylcarbamazine citrate therapy.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Headache: transient cranial discomfort. - Dizziness: occasional light‑headedness. - Abdominal pain: cramp‑like discomfort. - Fever: low‑grade temperature elevation. - Itching: pruritic skin sensations.

Serious or Rare Side Effects: - Anaphylaxis: severe allergic reaction requiring immediate medical attention. - Hepatic dysfunction: elevated liver enzymes or jaundice. - Neutropenia: marked reduction in neutrophil count. - Encephalopathy: altered mental status or seizures. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Cardiac arrhythmia: irregular heart rhythm.

What precautions apply to Diethylcarbamazine Citrate?

Careful assessment and monitoring are recommended when prescribing diethylcarbamazine citrate. - Renal function assessment: evaluate kidney status before initiation. - Allergic reaction monitoring: watch for signs of hypersensitivity. - Known hypersensitivity avoidance: do not use in patients with documented allergy to the drug. - Cardiac disease caution: use carefully in patients with pre‑existing heart conditions. - Pregnancy safety: safety not established; weigh benefits against potential risks. - Store at ambient temperature: keep in the original pack, protect from moisture.

What does Diethylcarbamazine Citrate interact with?

Diethylcarbamazine citrate may interact with other medicines, requiring attention to co‑administration.

Major Interactions (Avoid): - Anticoagulants: may increase bleeding risk. - MAO inhibitors: can potentiate hypotensive effects. - Other filaricidal agents: combined use may raise toxicity.

Moderate Interactions (Monitor Closely): - CYP450 substrates: diethylcarbamazine may alter plasma concentrations of drugs metabolised by these enzymes. - Antihistamines: may mask early allergic signs. - Diuretics: concurrent use may affect electrolyte balance.

Frequently asked questions

What conditions is Notezine used to treat?+
Notezine contains diethylcarbamazine citrate and is prescribed for infections caused by filarial parasites, specifically lymphatic filariasis, loiasis, and onchocerciasis. It helps reduce microfilarial counts and mitigates disease manifestations associated with these parasitic infections.
How does diethylcarbamazine citrate work against filarial parasites?+
Diethylcarbamazine citrate interferes with arachidonic acid metabolism in microfilariae, leading to their immobilisation and death. It also affects adult filarial worms by disrupting their metabolic pathways, thereby reducing parasite viability and aiding in disease control.
What is the usual dose of Notezine?+
The dosage of Notezine is determined by the prescribing clinician based on the patient’s age, weight, infection severity, and local treatment guidelines. Healthcare professionals set the appropriate regimen to ensure efficacy and safety.
Is Notezine safe to use during pregnancy or breastfeeding?+
Safety data for diethylcarbamazine citrate in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.
How do I order Notezine from GNH USA?+
To request Notezine, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Notezine compare with other antifilarial drugs?+
Compared with alternatives such as ivermectin or albendazole, diethylcarbamazine citrate has a distinct mechanism targeting arachidonic acid metabolism, offering rapid microfilarial clearance. Choice of therapy depends on regional parasite species, resistance patterns, and patient‑specific factors.
What are the recommended storage conditions for Notezine?+
Notezine should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.
How is Notezine administered?+
Notezine is taken orally as directed by a healthcare professional. The tablets are swallowed whole with water, usually on an empty stomach, unless the prescriber advises otherwise. Adherence to the prescribed schedule is essential for optimal therapeutic effect.
What are the most serious risks associated with Notezine?+
Serious adverse events, though rare, include severe allergic reactions such as anaphylaxis, hepatic dysfunction, neutropenia, encephalopathy, severe skin reactions like Stevens‑Johnson syndrome, and cardiac arrhythmias. Immediate medical attention is required if any of these occur.
Who should not use Notezine?+
Notezine is contraindicated in individuals with known hypersensitivity to diethylcarbamazine citrate or any of its excipients. Caution is also advised for patients with severe cardiac disease, uncontrolled hepatic impairment, or those who have experienced serious adverse reactions to similar anthelmintic agents.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Diethylcarbamazine Citrate
Route
Oral Use
Manufacturer
Sanofi Winthrop Industrie
Origin
EU