GNH USA

Europe — EMA

Notaxo (Ebastine)

GNH USA supplies Notaxo (Ebastine), a H1 antihistamine for allergic rhinitis and chronic idiopathic urticaria.

Ebastine

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What is Ebastine?

Ebastine, the active ingredient in Notaxo, is a second-generation H1 antihistamine presented as an oral tablet for oral use. It treats allergic rhinitis and chronic idiopathic urticaria in adults and adolescents. GNH USA supplies Notaxo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Ebastine used for?

Ebastine acts on histamine‑mediated allergic pathways, providing relief in several allergic conditions. Allergic rhinitis: reduces nasal congestion, sneezing and itching associated with seasonal or perennial allergies. Chronic idiopathic urticaria: alleviates persistent hives and associated itching. Allergic skin itching (pruritus): helps control itching caused by allergic skin reactions.

What are the side effects of Ebastine?

Common Side Effects: - Headache: mild to moderate pain often reported. - Dry mouth: sensation of reduced salivation. - Drowsiness: occasional mild sedation. - Fatigue: feeling of reduced energy. - Nausea: mild gastrointestinal upset. - Dizziness: transient light‑headedness.

Serious or Rare Side Effects: - Angioedema: swelling of face, lips or throat. - Severe skin reactions: such as Stevens‑Johnson syndrome. - Cardiac arrhythmia: irregular heart rhythm in susceptible individuals. - Anaphylaxis: rare systemic allergic reaction requiring immediate medical attention.

What precautions apply to Ebastine?

Before using Notaxo, consider the following precautions. Pregnancy: consult a healthcare professional before use. Breastfeeding: weigh potential risks and benefits with a physician. Renal impairment: dose may need adjustment in severe cases. Elderly: monitor for increased sedation or dizziness. Drug interactions: review all concomitant medications. Store at ambient temperature: keep in the original container, protect from moisture and light.

What does Ebastine interact with?

Ebastine may interact with several medicines; monitoring is advised. Major Interactions (Avoid): - Ketoconazole: may increase ebastine plasma concentrations. - Erythromycin: can raise ebastine levels, increasing side‑effect risk. - Ritonavir: may markedly elevate ebastine exposure. Moderate Interactions (Monitor Closely): - Theophylline: potential for enhanced central effects. - CNS depressants: additive sedation may occur. - Alcohol: may increase drowsiness and dizziness.

Frequently asked questions

What conditions is Notaxo used for?+
Notaxo contains ebastine, which is prescribed to relieve symptoms of allergic rhinitis, such as sneezing, runny nose and itching, as well as to manage chronic idiopathic urticaria, reducing hives and associated itching.
How does ebastine work in the body?+
Ebastine works by selectively blocking peripheral H1 histamine receptors, preventing histamine from triggering the cascade that leads to allergy symptoms like swelling, itching, and nasal congestion.
What is the usual dose of Notaxo?+
The appropriate dose of Notaxo is determined by the prescribing healthcare professional based on the patient’s age, condition severity, and overall health status.
Is Notaxo safe during pregnancy or breastfeeding?+
Safety data for ebastine in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before using Notaxo.
How do I order Notaxo from GNH USA?+
To order Notaxo, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Notaxo compare with other antihistamines?+
Compared with first‑generation antihistamines, ebastine (Notaxo) offers effective allergy relief with a lower likelihood of sedation because it does not readily cross the blood‑brain barrier. It is similar in efficacy to other second‑generation agents such as cetirizine or loratadine.
What are the recommended storage conditions for Notaxo?+
Notaxo should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children.
How is Notaxo administered?+
Notaxo is taken orally, usually with a glass of water. It can be taken with or without food, as directed by the prescribing clinician.
What are the most serious risks associated with Notaxo?+
Serious but rare risks include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, cardiac arrhythmias, and anaphylaxis. Patients should seek immediate medical attention if they experience swelling of the face or throat, rash, or difficulty breathing.
Who should not use Notaxo?+
Notaxo should be avoided in individuals with known hypersensitivity to ebastine or any of the tablet’s excipients. Caution is also advised for patients with severe hepatic impairment, as well as those taking medications that strongly inhibit CYP3A4 without medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Ebastine
Route
Oral Use
Manufacturer
Stada Arzneimittel Ag
Origin
EU

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