GNH USA

Europe — EMA

Nosatel (Dexketoprofen)

GNH USA supplies Nosatel (Dexketoprofen), a non‑steroidal anti‑inflammatory drug for moderate, post‑operative and musculoskeletal pain. Request a quote.

Dexketoprofen

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What is Dexketoprofen?

Dexketoprofen, the active ingredient in Nosatel, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an injectable solution for intramuscular and intravenous use. It is indicated for the management of moderate pain, post‑operative discomfort and musculoskeletal pain in adult patients.

GNH USA supplies Nosatel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The company provides regulatory‑approved batches to healthcare facilities across Europe, Asia and the Americas.

What is Dexketoprofen used for?

Dexketoprofen is employed to relieve pain by inhibiting inflammatory pathways.

- Moderate acute pain: provides rapid analgesia for pain of moderate intensity. - Post‑operative pain: reduces pain and inflammation after surgical procedures. - Musculoskeletal pain: alleviates pain associated with strains, sprains and other musculoskeletal conditions.

What are the side effects of Dexketoprofen?

Dexketoprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea - Dyspepsia - Headache - Dizziness - Injection‑site pain or erythema - Mild skin rash

Serious or Rare Side Effects: - Gastrointestinal bleeding or ulceration - Severe renal impairment - Anaphylactic or severe hypersensitivity reactions - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Cardiovascular thrombotic events - Hepatic dysfunction

What precautions apply to Dexketoprofen?

When using Dexketoprofen, several safety considerations should be observed.

- Assess renal function: avoid use in patients with severe renal impairment. - Monitor gastrointestinal risk: use with caution in individuals with a history of ulcers or bleeding. - Avoid in known hypersensitivity: discontinue if allergic reactions occur. - Consider cardiovascular risk: NSAIDs may increase thrombotic events, use cautiously in patients with cardiovascular disease. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Dexketoprofen interact with?

Dexketoprofen can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid): - Anticoagulants (e.g., warfarin): increased bleeding risk. - Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity. - Selective serotonin reuptake inhibitors (SSRIs): heightened risk of bleeding. - ACE inhibitors or diuretics: may reduce renal function. - Lithium: NSAIDs can raise lithium levels.

Moderate Interactions (Monitor Closely): - Methotrexate: reduced clearance, monitor levels. - Corticosteroids: increased ulcer risk. - Beta‑blockers: may blunt antihypertensive effect.

Frequently asked questions

What is Nosatel used for?+
Nosatel contains dexketoprofen, an NSAID indicated for the relief of moderate acute pain, post‑operative pain and musculoskeletal pain. It is administered by injection to provide rapid analgesia and reduce inflammation in adult patients.
How does dexketoprofen work?+
Dexketoprofen works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which blocks the synthesis of prostaglandins. Lower prostaglandin levels reduce peripheral sensitisation of pain receptors and diminish inflammatory responses, producing analgesic and anti‑inflammatory effects.
What is the usual dose of Nosatel?+
The specific dose of Nosatel is determined by the prescribing clinician based on the patient’s condition, severity of pain, and clinical judgement. Dosage may vary according to the route of administration (intramuscular or intravenous) and individual patient factors.
Is Nosatel safe in pregnancy or breastfeeding?+
Safety of dexketoprofen during pregnancy and lactation has not been firmly established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and only under the guidance of a qualified healthcare professional.
How do I order Nosatel from GNH USA?+
To order Nosatel, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.
How does Nosatel compare with other NSAIDs?+
Nosatel delivers dexketoprofen, which is the S‑enantiomer of ketoprofen and provides potent analgesia at lower doses compared with many traditional NSAIDs. Its rapid onset and injectable formulation make it useful for acute pain settings, while the safety profile is similar to other non‑selective NSAIDs, requiring attention to gastrointestinal, renal and cardiovascular risks.
How should Nosatel be stored and handled?+
Nosatel should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Keep the product in its original packaging until use to maintain stability and sterility.
How is Nosatel administered?+
Nosatel is supplied as a sterile injectable solution and may be given either intramuscularly or intravenously by a qualified healthcare professional. The injection should be performed using aseptic technique, and the dose is administered over the time period recommended by the prescriber.
What are the most serious risks to watch for with Nosatel?+
Serious risks include gastrointestinal bleeding or ulceration, severe renal impairment, hypersensitivity reactions such as anaphylaxis, and cardiovascular events like myocardial infarction or stroke. Patients should be monitored for signs of bleeding, renal dysfunction, allergic reactions, and any new or worsening cardiovascular symptoms.
Who should not use Nosatel?+
Nosatel should be avoided in patients with known hypersensitivity to dexketoprofen or other NSAIDs, those with active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, and individuals with established high cardiovascular risk unless the benefit outweighs the risk. It is also contraindicated in patients receiving other non‑selective NSAIDs concurrently.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Dexketoprofen
Route
Intramuscular Use , Intravenous Use
Manufacturer
Menarini International Operations Luxembourg S.A.
Origin
EU

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