Europe — EMA
Norvasc (Amlodipine)
GNH USA supplies Norvasc (Amlodipine), a calcium channel blocker for hypertension and stable angina. Request a quote for supply to hospitals and pharmacies.
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What is Amlodipine?
Amlodipine, the active ingredient in Norvasc, is a calcium channel blocker presented as an oral tablet for oral use. It works by relaxing vascular smooth muscle, thereby lowering blood pressure and improving blood flow to the heart. The medication is indicated for the management of hypertension and for relief of chronic stable angina in adult patients, helping to reduce the frequency of angina attacks and the risk of cardiovascular complications.
GNH USA supplies Norvasc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.
What is Amlodipine used for?
Norvasc (amlodipine) is used in cardiovascular disease management, primarily affecting blood pressure regulation and myocardial oxygen demand.
Hypertension: reduces systemic vascular resistance and lowers blood pressure. Chronic stable angina: improves coronary blood flow and decreases frequency of angina episodes. Vasospastic (Prinzmetal) angina: prevents coronary artery spasm and relieves chest pain.
What are the side effects of Amlodipine?
Amlodipine may cause a range of adverse reactions, varying from mild to severe.
Common Side Effects: - Peripheral edema: swelling of the ankles or feet. - Headache: mild to moderate intensity. - Dizziness: feeling light‑headed or unsteady.
Serious or Rare Side Effects: - Severe hypotension: markedly low blood pressure. - Myocardial infarction: chest pain indicative of heart attack. - Stevens‑Johnson syndrome: severe skin reaction.
What precautions apply to Amlodipine?
Before initiating therapy, consider patient‑specific factors and monitor for adverse events.
Renal impairment: use with caution and monitor blood pressure. Hepatic impairment: dose adjustment may be required. Concomitant beta‑blockers: may enhance hypotensive effect. Pregnancy: risk unknown; prescribe only if clearly needed. Elderly patients: start at lower dose and monitor for edema. Store at ambient temperature: keep below 25 °C, in original packaging, protect from moisture.
What does Amlodipine interact with?
Amlodipine can interact with several medicines, altering its efficacy or safety profile.
Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): increase amlodipine plasma levels. - Simvastatin high dose: increased risk of myopathy. - Grapefruit juice: may raise amlodipine exposure.
Moderate Interactions (Monitor Closely): - Beta‑blockers: additive blood pressure lowering. - Diuretics: may potentiate hypotensive effect. - Rifampin: may reduce amlodipine concentration.
