GNH USA

Europe — EMA

Norprolac (Quinagolide)

GNH USA supplies Norprolac (Quinagolide), a dopamine agonist for hyperprolactinemia and prolactin‑secreting pituitary adenomas.

Quinagolide

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What is Quinagolide?

Quinagolide, the active ingredient in Norprolac, is a dopamine agonist presented as an oral tablet for oral use. It treats hyperprolactinemia and prolactin‑secreting pituitary adenomas in adult patients.

GNH USA supplies Norprolac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Quinagolide used for?

Quinagolide acts on the dopaminergic pathway to lower excess prolactin levels, making it useful in several endocrine conditions.

- Hyperprolactinemia: reduces serum prolactin and normalises menstrual cycles and sexual function. - Prolactin‑secreting pituitary adenomas: shrinks tumor size and alleviates associated symptoms. - Galactorrhea due to hyperprolactinemia: stops inappropriate breast milk production.

What are the side effects of Quinagolide?

Adverse reactions may vary in frequency and severity.

Common Side Effects: - Nausea: mild to moderate gastrointestinal upset. - Headache: transient tension‑type headaches. - Dizziness: occasional light‑headedness, especially on standing. - Fatigue: generalised tiredness during early therapy.

Serious or Rare Side Effects: - Valvular heart disease: rare but may present with murmurs. - Impulse control disorders: compulsive behaviours such as gambling. - Severe hypotension: marked blood pressure drop requiring medical attention.

What precautions apply to Quinagolide?

Before initiating therapy, consider the following safety measures.

- Pregnancy: avoid unless the potential benefit justifies the risk to the fetus. - Breastfeeding: not recommended as the drug may be excreted in milk. - Renal impairment: assess kidney function; dose adjustment may be required. - Cardiovascular disease: monitor blood pressure and cardiac status. - Drug interactions: review concomitant medications for potential conflicts. - Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

What does Quinagolide interact with?

Quinagolide may interact with several drug classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid): - Antipsychotics (e.g., haloperidol): antagonise dopamine receptors and diminish efficacy. - Ergot alkaloids: additive vasospasm risk leading to peripheral ischemia. - MAO inhibitors: potential for hypertensive crisis.

Moderate Interactions (Monitor Closely): - Antihypertensives: may cause additive hypotensive effects. - SSRIs: possible increase in serotonin syndrome risk. - Hormonal contraceptives: may alter prolactin dynamics and affect efficacy.

Frequently asked questions

What is Norprolac used for?+
Norprolac contains quinagolide, a dopamine agonist prescribed to lower elevated prolactin levels. It is indicated for treating hyperprolactinemia and prolactin‑secreting pituitary adenomas, helping to restore normal hormonal balance and alleviate related symptoms such as menstrual disturbances and galactorrhea.
How does quinagolide work?+
Quinagolide selectively activates dopamine D2 receptors in the anterior pituitary gland. This activation suppresses adenylate cyclase activity, leading to reduced secretion of prolactin. By decreasing circulating prolactin, the drug corrects the hormonal excess that causes the clinical manifestations of hyperprolactinemia.
What is the usual dose of Norprolac?+
The appropriate dose of Norprolac is determined by the prescribing clinician based on the individual’s condition, response, and tolerability. Dosage adjustments are made according to therapeutic goals and any relevant patient factors, such as renal function or concomitant medications.
Is Norprolac safe during pregnancy or breastfeeding?+
Quinagolide is generally not recommended during pregnancy unless the potential benefit outweighs the risk to the fetus. It is also contraindicated while breastfeeding because the drug can be excreted in breast milk and may affect the infant.
How do I order Norprolac from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Norprolac compare with other treatments for hyperprolactinemia?+
Norprolac (quinagolide) is a selective dopamine D2‑receptor agonist, similar to cabergoline and bromocriptine. Compared with bromocriptine, quinagolide often has a shorter half‑life and may be associated with fewer gastrointestinal side effects, while cabergoline typically requires less frequent dosing but carries a higher risk of valvular heart disease.
What are the storage requirements for Norprolac?+
Norprolac tablets should be stored at temperatures below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.
How is Norprolac administered?+
Norprolac is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed. Administration timing (e.g., with meals or on an empty stomach) is guided by the prescribing physician based on individual tolerability.
What are the most serious risks associated with Norprolac?+
Serious adverse events, though rare, include valvular heart disease, impulse control disorders such as compulsive gambling, and severe hypotension. Patients should be monitored for cardiac symptoms, changes in behaviour, and any sudden drops in blood pressure, and report these promptly to their healthcare provider.
Who should not use Norprolac?+
Norprolac is contraindicated in individuals with known hypersensitivity to quinagole or any excipients, patients with uncontrolled hypertension, and those taking potent dopamine antagonists. Caution is also advised for patients with significant cardiac disease, renal impairment, or a history of impulse control disorders.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Quinagolide
Route
Oral Use
Manufacturer
Ferring Léciva A.S.
Origin
EU

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