Norlevo (Levonorgestrel)

Levonorgestrel, the active ingredient in Norlevo, is a progestin presented as a 1.5 mg tablet for oral use. It is used as an emergency contraceptive to prevent pregnancy after unprotected intercourse and works by delaying ovulation, potentially inhibiting fertilization and altering endometrial receptivity. It is available over‑the‑counter in many EU countries and is indicated for use within 72 hours of intercourse.

GNH USA supplies Norlevo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for cross‑border distribution.

Levonorgestrel in Norlevo is used as an emergency contraceptive acting on the reproductive hormonal pathway. - Unprotected sexual intercourse: reduces the risk of pregnancy when administered within 72 hours after exposure. - Contraceptive failure (e.g., missed oral contraceptive pill): offers a backup method to prevent unintended pregnancy. - Post‑coital emergency use: provides a non‑prescription option for immediate pregnancy prevention.

Levonorgestrel is generally well tolerated, but several adverse reactions have been reported.

Common Side Effects: - Nausea: mild to moderate upset stomach occurring shortly after ingestion. - Headache: transient tension‑type headache. - Abdominal pain or cramps: discomfort in the lower abdomen. - Menstrual changes: spotting, earlier or later onset of the next period. - Fatigue or dizziness: temporary feeling of tiredness.

Serious or Rare Side Effects: - Allergic reaction: rash, itching, swelling, or anaphylaxis. - Severe abdominal pain: may indicate ectopic pregnancy. - Chest pain or shortness of breath: possible cardiovascular involvement. - Persistent vomiting: could lead to dehydration. - Liver dysfunction: jaundice or abnormal liver enzymes.

Before using Norlevo, consider the following safety measures. - Timing of intake: take as soon as possible after unprotected intercourse, ideally within 72 hours. - Pregnancy status: not indicated for use during an established pregnancy. - Breastfeeding: consult a healthcare professional before use. - Drug interactions: avoid concomitant use with enzyme‑inducing medicines that may lower effectiveness. - Medical conditions: use with caution in women with known hormonal disorders or liver disease. - Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture and direct sunlight.

Levonorgestrel may interact with other medicines, altering its efficacy.

Major Interactions (Avoid): - Rifampicin, carbamazepine, phenytoin, St. John’s wort: strong enzyme inducers that can markedly reduce contraceptive effectiveness. - Antiepileptic drugs: may lower plasma levels of levonorgestrel.

Moderate Interactions (Monitor Closely): - Antifungal azoles (e.g., ketoconazole): may increase levonorgestrel concentrations. - HIV protease inhibitors: can affect hormone metabolism. - Hormonal contraceptives: concurrent use may require additional counseling to ensure adequate protection.