GNH USA

Europe — EMA

Norfloxacine Zentiva

GNH USA supplies Norfloxacine Zentiva (Norfloxacin), a fluoroquinolone antibiotic for urinary tract infections, prostatitis and gastrointestinal infections.

Norfloxacin

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What is Norfloxacin?

Norfloxacin, the active ingredient in Norfloxacine Zentiva, is a fluoroquinolone antibiotic presented as an oral tablet for systemic use. It treats bacterial infections such as urinary tract infections, prostatitis, and certain gastrointestinal infections in adult patients, and is marketed in the European Union.

GNH USA supplies Norfloxacine Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across all markets. The company follows validated supply chains and provides regulatory documentation to support import.

What is Norfloxacin used for?

Norfloxacin is a fluoroquinolone antibiotic used to treat infections of the urinary and gastrointestinal tracts and the prostate. - Urinary tract infection: eradicates susceptible bacteria, relieving symptoms and preventing recurrence. - Prostatitis: reduces bacterial load in the prostate, improving clinical outcomes. - Gastrointestinal infection: treats infections caused by susceptible organisms such as traveler's diarrhea, aiding symptom resolution.

What are the side effects of Norfloxacin?

Norfloxacin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea: mild stomach upset or queasiness. - Diarrhea: loose stools, sometimes watery. - Headache: transient cranial discomfort. - Dizziness: feeling of lightheadedness or unsteadiness.

Serious or Rare Side Effects: - Tendon rupture: sudden tendon pain or rupture, especially in the Achilles. - QT prolongation: abnormal heart rhythm that may cause palpitations. - Severe allergic reaction: rash, swelling, or difficulty breathing indicating anaphylaxis.

What precautions apply to Norfloxacin?

When prescribing norfloxacin, clinicians should consider several safety precautions. - Renal impairment: adjust use or monitor kidney function. - Hepatic dysfunction: use with caution in patients with liver disease. - Concomitant QT‑prolonging drugs: avoid combined use to reduce cardiac risk. - History of tendon disorders: avoid in patients with prior tendon injury. - Pregnancy and breastfeeding: safety not established; use only if benefits outweigh risks. - Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

What does Norfloxacin interact with?

Norfloxacin can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: reduce absorption; separate dosing by at least 2 hours. - Warfarin: may increase anticoagulant effect; monitor INR closely. - Non‑steroidal anti‑inflammatory drugs (NSAIDs): increase risk of central nervous system stimulation and seizures.

Moderate Interactions (Monitor Closely): - Theophylline: may raise plasma levels; monitor for toxicity. - Cyclosporine: increased risk of nephrotoxicity; monitor renal function. - Corticosteroids: heightened risk of tendon rupture; advise caution.

Frequently asked questions

What is Norfloxacine Zentiva used for?+
Norfloxacine Zentiva contains norfloxacin, a fluoroquinolone antibiotic indicated for the treatment of uncomplicated urinary tract infections, acute bacterial prostatitis, and certain gastrointestinal infections caused by susceptible bacteria. It is prescribed for adult patients when a bacterial cause has been identified or is strongly suspected.
How does norfloxacin work?+
Norfloxacin exerts its antibacterial effect by binding to bacterial DNA gyrase and topoisomerase IV, enzymes that control DNA supercoiling and replication. Inhibiting these enzymes blocks DNA synthesis and transcription, leading to bacterial cell death and clearance of the infection.
What determines the dose of Norfloxacine Zentiva?+
The dose of Norfloxacine Zentiva is individualized by the prescribing healthcare professional based on the type and severity of infection, patient age, renal function, and other clinical factors. Patients should follow the exact regimen provided by their prescriber and not adjust the dose on their own.
Is Norfloxacine Zentiva safe in pregnancy or breastfeeding?+
Safety of norfloxacin during pregnancy and lactation has not been definitively established. It should only be used when the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified prescriber after careful evaluation.
How do I order Norfloxacine Zentiva from GNH USA?+
To order Norfloxacine Zentiva, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.
How does norfloxacin compare with other fluoroquinolones?+
Norfloxacin shares the class‑wide mechanism of DNA gyrase inhibition with other fluoroquinolones but differs in its spectrum of activity and pharmacokinetic profile. Compared with agents such as ciprofloxacin, norfloxacin often has a similar efficacy for urinary and gastrointestinal infections but may have a slightly different dosing frequency and tissue penetration, influencing choice based on infection site and patient factors.
How should Norfloxacine Zentiva be stored and handled?+
Norfloxacine Zentiva tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container to protect them from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity or direct sunlight.
How is Norfloxacine Zentiva administered?+
Norfloxacine Zentiva is taken orally, usually with a full glass of water. It may be taken with or without food, but patients should avoid concurrent intake of antacids containing aluminum or magnesium, as these can reduce absorption. The exact timing relative to meals should follow the prescriber's instructions.
What are the most serious risks to watch for with Norfloxacine Zentiva?+
Serious adverse effects include tendon rupture or tendinitis, especially in the Achilles tendon, QT interval prolongation leading to cardiac arrhythmias, and severe hypersensitivity reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience sudden tendon pain, palpitations, fainting, or signs of an allergic reaction.
Who should not use Norfloxacine Zentiva?+
Norfloxacine Zentiva should be avoided in patients with a known hypersensitivity to norfloxacin or other fluoroquinolones, those with a history of tendon disorders related to fluoroquinolone use, and individuals taking medications that significantly prolong the QT interval. Caution is also advised for patients with severe renal or hepatic impairment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Norfloxacin
Route
Oral Use
Manufacturer
Zentiva France
Origin
EU

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