Norazide (Hydrochlorothiazide, Ramipril)

Hydrochlorothiazide and Ramipril, the active ingredients in Norazide, are a thiazide diuretic and an ACE inhibitor presented as an oral tablet for systemic use. Together they lower elevated blood pressure and are indicated for the management of hypertension in adult patients.

GNH USA supplies Norazide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for regulated markets. The company adheres to EU quality standards and offers batch‑controlled products with full documentation for importers.

Norazide combines a thiazide diuretic and an ACE inhibitor and is used in the management of hypertension.

- Hypertension: reduces systolic and diastolic blood pressure in patients with primary hypertension. - Resistant or high‑risk hypertension: provides additive blood‑pressure control when monotherapy is insufficient. - Hypertensive patients with diabetic nephropathy: offers blood‑pressure reduction while helping to preserve renal function.

Common Side Effects: - Dizziness or light‑headedness: may occur with rapid blood‑pressure decline. - Increased urination: result of the diuretic component. - Cough: typical of ACE‑inhibitor therapy. - Electrolyte disturbances (e.g., low potassium): due to enhanced sodium loss.

Serious or Rare Side Effects: - Angioedema: swelling of face, lips, tongue, or airway. - Severe hypotension: especially after first dose or in volume‑depleted patients. - Acute renal impairment: marked rise in serum creatinine or reduced urine output.

Before initiating therapy, consider the following precautions: - Blood pressure monitoring: ensure adequate control and avoid excessive hypotension. - Renal function assessment: check serum creatinine and eGFR periodically. - Electrolyte balance: monitor potassium and sodium levels, especially in patients on other diuretics. - Pregnancy and lactation: avoid use unless benefits outweigh potential risks. - Elderly patients: start at lower doses and monitor for orthostatic symptoms. - Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Norazide may interact with several medicines.

Major Interactions (Avoid): - Potassium‑sparing diuretics or supplements: risk of hyperkalaemia. - Non‑steroidal anti‑inflammatory drugs (NSAIDs): may blunt antihypertensive effect and impair renal function. - Lithium: increased lithium levels leading to toxicity.

Moderate Interactions (Monitor Closely): - Other antihypertensives (beta‑blockers, calcium channel blockers): may cause additive blood‑pressure lowering. - Antidiabetic agents: possible enhancement of hypoglycaemic effect.