Nopregy (Levonorgestrel)

Levonorgestrel, the active ingredient in Nopregy, is a progestin presented as an oral tablet for oral use. It is employed to prevent or delay ovulation and to provide emergency contraception after unprotected sexual intercourse.

GNH USA supplies Nopregy as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Levonorgestrel acts within the hormonal contraceptive pathway to prevent unintended pregnancy. - Emergency contraception: provides post‑coital protection when taken promptly after unprotected intercourse. - Prevention of unintended pregnancy: used as a single dose to reduce the risk of pregnancy following contraceptive failure. - Ovulation inhibition (as part of emergency regimen): suppresses the release of an egg to avoid fertilisation.

Levonorgestrel is generally well tolerated, but adverse reactions can occur.

Common Side Effects: - Nausea - Headache - Fatigue - Dizziness - Abdominal pain - Menstrual changes

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) - Thromboembolic events - Liver dysfunction

Levonorgestrel should be used with awareness of specific safety considerations. - Timing of administration: take as soon as possible, ideally within 72 hours after unprotected intercourse. - Contraindications: avoid if known hypersensitivity to levonorgestrel or other progestins. - Medical conditions: caution in women with a history of thromboembolic disorders, liver disease, or hormone‑sensitive cancers. - Drug interactions: review concomitant medications that may reduce efficacy. - Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Levonorgestrel may interact with other medicines, altering its effectiveness.

Major Interactions (Avoid): - Enzyme inducers such as rifampicin, which can lower plasma levels. - Anticonvulsants like carbamazepine that accelerate metabolism. - St. John’s wort, a herbal inducer of CYP3A4.

Moderate Interactions (Monitor Closely): - Hormonal therapies (e.g., combined oral contraceptives) that may have additive hormonal effects. - Antifungal azoles (e.g., ketoconazole) that can affect hormone metabolism. - Certain antiretrovirals (e.g., protease inhibitors) that may modify drug levels.