Nomigrin (Naproxen Sodium, Sumatriptan Succinate)

Naproxen sodium and sumatriptan succinate, the active ingredients in Nomigrin, constitute an NSAID/Triptan combination presented as an oral tablet for oral administration. The product is indicated for the acute treatment of migraine attacks in adult patients, aiming to relieve headache and associated symptoms.

GNH USA supplies Nomigrin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support global distribution. Customers benefit from reliable supply chains and responsive technical support.

Nomigrin, a combined NSAID and triptan therapy, is used for the acute management of migraine.

Migraine without aura: rapid relief of headache and associated nausea. Migraine with aura: reduction of aura severity and quicker resolution of headache. Acute migraine attacks: alleviation of pain, photophobia, phonophobia and vomiting.

Common Side Effects: - Nausea: mild to moderate upset stomach. - Dizziness: transient light‑headedness. - Dry mouth: reduced salivation. - Fatigue: feeling of tiredness. - Abdominal pain: mild discomfort.

Serious or Rare Side Effects: - Cardiovascular events: chest pain, hypertension, or arrhythmia. - Serotonin syndrome: agitation, hyperthermia, muscle rigidity. - Severe allergic reaction: rash, swelling, airway compromise. - Hepatic dysfunction: jaundice or elevated liver enzymes. - Gastrointestinal bleeding: black stools or vomiting blood.

Before initiating therapy, consider the following precautions: - Cardiovascular risk assessment: evaluate history of heart disease or uncontrolled hypertension. - Contraindication with uncontrolled hypertension: avoid use in patients with severe high blood pressure. - Caution with other NSAIDs: increased risk of gastrointestinal bleeding. - Avoid concomitant serotonergic agents: risk of serotonin syndrome. - Monitor for allergic reactions: discontinue if signs of hypersensitivity appear. - Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Nomigrin may interact with several drug classes. Review patient medication history carefully.

Major Interactions (Avoid): - MAO inhibitors: risk of severe serotonin syndrome. - Other triptans or ergot derivatives: additive vasoconstriction. - SSRIs/SNRIs or other serotonergic agents: heightened serotonin toxicity. - Anticoagulants (e.g., warfarin): increased bleeding risk. - CYP2C9 inhibitors (e.g., fluconazole): elevated naproxen levels.

Moderate Interactions (Monitor Closely): - Additional NSAIDs: cumulative gastrointestinal risk. - Antihypertensives: possible reduction in blood pressure control. - Oral contraceptives: may increase thrombotic risk. - Diuretics: potential renal function impact. - CYP3A4 inhibitors (e.g., erythromycin): modest increase in sumatriptan exposure.