Nolvac (Amlodipine)

Amlodipine, the active ingredient in Nolvac, is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension and chronic stable angina in adult patients.

GNH USA supplies Nolvac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Amlodipine is used to manage conditions that involve elevated vascular resistance and myocardial oxygen demand. - Hypertension: lowers blood pressure by relaxing arterial smooth muscle, reducing cardiovascular risk. - Chronic stable angina: improves chest pain control by increasing coronary blood flow. - Cardiovascular risk reduction in hypertensive patients: contributes to long‑term prevention of stroke and heart attack when combined with lifestyle measures.

Amlodipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Headache: mild to moderate intensity, often transient. - Flushing: sensation of warmth, especially on the face. - Peripheral edema: swelling of ankles or lower legs. - Dizziness or light‑headedness, particularly after standing. - Fatigue: general tiredness without specific cause. - Palpitations: awareness of heartbeat.

Serious or Rare Side Effects: - Severe hypotension: marked drop in blood pressure requiring medical attention. - Myocardial infarction: rare occurrence, especially in patients with pre‑existing coronary disease. - Hepatic dysfunction: elevated liver enzymes or jaundice. - Allergic reactions: rash, itching, or anaphylaxis. - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Blood dyscrasias: neutropenia or thrombocytopenia.

Before initiating amlodipine therapy, clinicians should assess individual risk factors and monitor patients for specific concerns. - Blood pressure monitoring: ensure adequate control without excessive hypotension. - Cardiac assessment: evaluate for heart failure or recent myocardial infarction. - Hepatic impairment: adjust use in patients with liver disease. - Concomitant antihypertensives: avoid additive hypotensive effects. - Abrupt discontinuation: taper to prevent rebound hypertension. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Amlodipine can interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole): may increase amlodipine plasma levels. - Concurrent use with other potent antihypertensives: risk of severe hypotension. - Grapefruit juice: can elevate drug concentrations.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce effectiveness. - Diuretics: may enhance blood‑pressure‑lowering effect. - NSAIDs: can attenuate antihypertensive response. - Digoxin: potential increase in serum digoxin levels.