GNH USA

Europe — EMA

Noliprel (Indapamide, Perindopril Arginine)

GNH USA supplies Noliprel (Indapamide/Perindopril arginine), a combination antihypertensive for the treatment of hypertension in adults.

Indapamide, Perindopril Arginine

Request sourcing

1
Pack/s

What is Indapamide, Perindopril Arginine?

Indapamide and Perindopril arginine, the active ingredients in Noliprel, are a combination antihypertensive (ACE inhibitor + thiazide‑like diuretic) presented as an oral tablet for adult use. The product is indicated for the management of hypertension, helping to lower elevated blood pressure in patients diagnosed with primary hypertension.

GNH USA supplies Noliprel as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product is sourced from EU manufacturers and meets European pharmacopoeial standards, ensuring consistent potency and safety for global distribution.

What is Indapamide, Perindopril Arginine used for?

Noliprel is a combination antihypertensive used to treat conditions related to high blood pressure.

- Hypertension: Reduces systolic and diastolic blood pressure, helping patients achieve target blood‑pressure goals.

What are the side effects of Indapamide, Perindopril Arginine?

Common Side Effects: - Dizziness: Light‑headed sensation, especially after standing. - Headache: Mild to moderate pressure sensation. - Cough: Dry, non‑productive cough. - Fatigue: Generalised tiredness. - Increased urination: Due to diuretic effect. - Electrolyte imbalance: Mild changes in potassium or sodium levels.

Serious or Rare Side Effects: - Angioedema: Swelling of face, lips, tongue, or airway. - Severe hypotension: Marked drop in blood pressure causing faintness. - Acute renal impairment: Sudden decrease in kidney function. - Hyperkalemia: Elevated potassium levels. - Pancreatitis: Inflammation of the pancreas. - Hepatic dysfunction: Abnormal liver enzyme elevations.

What precautions apply to Indapamide, Perindopril Arginine?

Before starting Noliprel, consider the following precautions.

- Monitor renal function: Check serum creatinine and eGFR at baseline and periodically. - Assess electrolytes: Evaluate potassium and sodium levels, especially in patients on other diuretics. - Watch for hypotension: Caution in volume‑depleted or elderly patients. - Avoid in pregnancy: Use only if benefits outweigh risks, as safety data are limited. - Contraindicated with aliskiren in diabetes: Do not combine with aliskiren in diabetic patients. - Store at ambient temperature: Keep below 25 °C, retain in original packaging, protect from moisture.

What does Indapamide, Perindopril Arginine interact with?

Noliprel may interact with several medicines; monitor accordingly.

Major Interactions (Avoid): - Potassium‑sparing diuretics or supplements: Risk of hyperkalemia. - Lithium: Increased lithium levels and toxicity. - NSAIDs: May blunt antihypertensive effect and impair renal function.

Moderate Interactions (Monitor Closely): - Other antihypertensives: Additive blood‑pressure lowering, risk of hypotension. - Antacids containing aluminum or magnesium: May reduce perindopril absorption. - CYP450 inhibitors (e.g., ritonavir): May increase perindopril concentrations.

Frequently asked questions

What is Noliprel used for?+
Noliprel is prescribed to lower high blood pressure in adults diagnosed with hypertension. It combines an ACE inhibitor with a thiazide‑like diuretic to achieve better blood‑pressure control than either component alone.
How does Indapamide/Perindopril arginine work?+
Perindopril arginine blocks the angiotensin‑converting enzyme, reducing angiotensin II formation and decreasing vasoconstriction. Indapamide inhibits sodium‑chloride reabsorption in the distal tubule, increasing urine output and lowering peripheral resistance. Together they produce a complementary antihypertensive effect.
What is the usual dose of Noliprel?+
The specific dose of Noliprel is determined by the prescribing clinician based on the patient’s blood‑pressure readings, renal function, and overall health status. Dosage adjustments are made according to clinical response and tolerability.
Is Noliprel safe during pregnancy or breastfeeding?+
Safety data for Noliprel in pregnancy are limited, and the product is generally avoided unless the potential benefit justifies the risk. Breastfeeding mothers should consult their healthcare provider, as the drug may be excreted in milk.
How do I order Noliprel from GNH USA?+
To request Noliprel, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.
How does Noliprel compare with other antihypertensive options?+
Compared with single‑agent ACE inhibitors or thiazide diuretics, Noliprel offers a dual mechanism that can achieve greater blood‑pressure reduction with a single tablet, potentially improving adherence. It is an alternative to other combination products such as lisinopril‑hydrochlorothiazide.
What are the storage and handling requirements for Noliprel?+
Store Noliprel at ambient temperature, below 25 °C, in the original container to protect it from moisture and light. Keep the tablet out of reach of children and do not use after the expiry date.
How is Noliprel administered?+
Noliprel is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a full glass of water; do not crush or chew unless instructed otherwise.
What are the most serious risks associated with Noliprel?+
Serious risks include angioedema (swelling of the face, lips, tongue, or airway), severe hypotension, acute kidney injury, and hyperkalemia. Patients should seek immediate medical attention if they experience symptoms such as swelling, difficulty breathing, sudden dizziness, or marked decrease in urine output.
Who should not use Noliprel?+
Noliprel is contraindicated in patients with known hypersensitivity to either component, those with severe renal impairment, hyperkalemia, or a history of angioedema related to ACE‑inhibitor therapy. It should also be avoided in patients taking aliskiren if they have diabetes.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
Send a sourcing enquiry for this product →

Product details

Drug
Indapamide, Perindopril Arginine
Route
Oral Use
Manufacturer
Les Laboratoires Servier (Suresnes)
Origin
EU

Related products

Bi Preterax Arginin

Bi Preterax Arginin

Indapamide, Perindopril Arginine

Servier Austria Gmbh
EU
Bionoliprel

Bionoliprel

Indapamide, Perindopril Arginine

Servier Pharma D.O.O
EU
Bioprexanil Combi

Bioprexanil Combi

Indapamide, Perindopril Arginine

Servier Pharma D.O.O
EU
Bipreterax

Bipreterax

Indapamide, Perindopril Arginine

Les Laboratoires Servier (Suresnes)
EU