Nolicin-S (Norfloxacin)

Norfloxacin, the active ingredient in Nolicin‑S, is a fluoroquinolone antibiotic presented as an oral tablet for oral use. It treats urinary tract infections, prostatitis and gastrointestinal infections in adult patients, targeting susceptible Gram‑negative and some Gram‑positive bacteria.

GNH USA supplies Nolicin‑S as a licensed, GDP‑compliant international pharmaceutical supplier, providing quality‑assured products to hospitals, pharmacies and clinics worldwide, with regulatory‑approved manufacturing and reliable distribution networks. The company adheres to WHO GMP guidelines and offers flexible packaging options to meet diverse market requirements.

Nolicin‑S (norfloxacin) is indicated for bacterial infections affecting the urinary, prostate and gastrointestinal tracts. - Urinary tract infection: eradicates susceptible uropathogens and resolves symptoms such as dysuria and frequency. - Prostatitis: reduces bacterial load in the prostate and alleviates inflammatory signs. - Gastrointestinal infection: treats infections caused by susceptible enteric bacteria, improving gastrointestinal symptoms.

Nolicin‑S may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Diarrhea: loose stools, usually self‑limiting. - Headache: transient cranial discomfort. - Dizziness: occasional vertigo or light‑headedness. - Photosensitivity: increased skin sensitivity to sunlight. - Rash: mild skin eruption.

Serious or Rare Side Effects: - Tendon rupture: risk of Achilles or other tendon tears, especially in older patients. - QT prolongation: potential cardiac arrhythmia requiring monitoring. - Severe allergic reaction: anaphylaxis, angioedema, or Stevens‑Johnson syndrome. - Elevated liver enzymes: possible hepatic enzyme elevation indicating liver stress.

Before prescribing Nolicin‑S, clinicians should consider several precautionary measures to ensure safe use. - Renal function: assess kidney function and adjust dose in impairment. - Hepatic function: monitor liver enzymes in patients with liver disease. - Age: use with caution in elderly patients due to increased tendon risk. - Concomitant fluoroquinolones: avoid combined use to prevent additive toxicity. - Phototoxicity: advise patients to limit sun exposure and use sunscreen. - Store at ambient temperature: keep below 25 °C in original packaging, protect from moisture.

Nolicin‑S can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Antacids containing aluminum or magnesium: reduce absorption of norfloxacin. - Warfarin: may increase anticoagulant effect and bleeding risk. - NSAIDs (e.g., ibuprofen, naproxen): increase risk of central nervous system stimulation and seizures.

Moderate Interactions (Monitor Closely): - Corticosteroids: heightened risk of tendon rupture. - Cyclosporine: may increase norfloxacin plasma levels. - Theophylline: potential for increased stimulation and seizures.