GNH USA

Europe — EMA

Nofebran (Metamizole Sodium Monohydrate)

GNH USA supplies Nofebran (Metamizole Sodium), a pyrazolone analgesic for pain relief and fever reduction. Request a quote for global supply.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole sodium, the active ingredient in Nofebran, is a pyrazolone analgesic presented as an oral tablet for oral use. It provides pain relief and reduces fever in adult and pediatric patients when prescribed by a healthcare professional.

GNH USA supplies Nofebran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

What is Metamizole Sodium Monohydrate used for?

Metamizole sodium is used to manage pain and fever across several clinical situations.

- Pain relief: Provides analgesia for moderate to severe acute pain. - Fever reduction: Lowers elevated body temperature in febrile states. - Post‑operative pain: Controls pain following surgical procedures. - Colic: Relieves visceral pain associated with gastrointestinal colic.

What are the side effects of Metamizole Sodium Monohydrate?

Metamizole sodium may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea - Vomiting - Dizziness - Headache - Skin rash - Transient hypotension

Serious or Rare Side Effects: - Agranulocytosis (severe neutropenia) - Anaphylactic or severe allergic reactions - Other blood dyscrasias - Hepatic dysfunction - Renal impairment

What precautions apply to Metamizole Sodium Monohydrate?

Before prescribing Metamizole sodium, clinicians should consider several safety measures.

- Assess blood counts before initiating therapy: monitor for neutropenia. - Avoid use in patients with known hypersensitivity to pyrazolones: discontinue if reaction occurs. - Use cautiously in patients with hepatic or renal impairment: dose adjustment may be required. - Do not combine with other NSAIDs or anticoagulants without medical supervision: increased bleeding risk. - Store at ambient temperature below 25°C: keep in original container, protect from moisture and light.

What does Metamizole Sodium Monohydrate interact with?

Metamizole sodium can interact with other medicines; some combinations require avoidance while others need close monitoring.

Major Interactions (Avoid): - Concurrent use with other strong COX inhibitors (e.g., high‑dose NSAIDs): may increase gastrointestinal toxicity. - Co‑administration with anticoagulants (warfarin, heparin): heightened bleeding risk. - Use with drugs causing bone‑marrow suppression (e.g., chlorpromazine): risk of agranulocytosis.

Moderate Interactions (Monitor Closely): - Combination with diuretics: may enhance hypotensive effect. - Interaction with antihypertensives: possible additive blood‑pressure lowering. - Use with other antipyretics (paracetamol): monitor for overlapping toxicity.

Frequently asked questions

What is Nofebran used for?+
Nofebran contains Metamizole sodium and is prescribed to relieve moderate to severe pain and to reduce fever. It is commonly used after surgery, for acute colic, and in other situations where rapid analgesic and antipyretic effects are needed.
How does Metamizole sodium work?+
Metamizole sodium works mainly by inhibiting cyclooxygenase (COX) enzymes, which lowers prostaglandin production. This reduction diminishes the signals that cause pain and fever, providing analgesic and antipyretic effects even though the full mechanism is not completely understood.
What is the usual dose of Nofebran?+
The dose of Nofebran is determined by the prescribing clinician based on the patient’s age, weight, severity of pain or fever, and overall health status. Only a qualified healthcare professional should set the dosage and frequency.
Is Nofebran safe in pregnancy or breastfeeding?+
Safety data for Metamizole sodium during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.
How do I order Nofebran from GNH USA?+
To order Nofebran, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Nofebran compare with other analgesics?+
Compared with traditional NSAIDs such as ibuprofen, Metamizole sodium often provides stronger analgesia and antipyretic effects with a different safety profile. However, it carries a risk of rare but serious blood‑cell disorders, which are less common with many other NSAIDs.
What are the storage and handling requirements for Nofebran?+
Nofebran should be stored at ambient temperature below 25 °C, in its original packaging, protected from moisture and direct light. Keeping the tablets in a dry, cool place helps maintain their potency throughout the shelf life.
How is Nofebran administered?+
Nofebran is taken orally. The tablets should be swallowed whole with a glass of water, preferably after a meal to reduce gastrointestinal discomfort, unless the prescriber advises otherwise.
What are the most serious risks associated with Nofebran?+
The most serious adverse reactions include agranulocytosis, a severe drop in white‑blood‑cell count, and life‑threatening allergic reactions such as anaphylaxis. Patients should be monitored for signs of infection or hypersensitivity, and treatment should be stopped immediately if these occur.
Who should not use Nofebran?+
Nofebran is contraindicated in individuals with known hypersensitivity to Metamizole or other pyrazolones, those with existing blood‑cell disorders, severe liver or kidney impairment, and patients who are currently receiving other strong COX inhibitors without medical supervision.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Oral Use
Manufacturer
Zentiva, K.S.
Origin
EU

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