GNH USA

Europe — EMA

Nofebran (Metamizole Sodium Monohydrate)

GNH USA supplies Nofebran (Metamizole Sodium Monohydrate), a pyrazolone analgesic for pain and fever.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole sodium monohydrate, the active ingredient in Nofebran, is a pyrazolone presented as an oral formulation for oral use. It is employed to relieve pain and reduce fever in adult patients.\n\nGNH India supplies Nofebran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Metamizole Sodium Monohydrate used for?

Nofebran, a pyrazolone analgesic, is indicated for conditions involving pain and elevated temperature.\n\n- Pain: Provides analgesic relief in moderate to severe acute pain.\n- Fever: Reduces high body temperature when antipyretic therapy is required.\n- Post‑operative pain: Assists in managing pain following surgical procedures.

What are the side effects of Metamizole Sodium Monohydrate?

Adverse reactions may occur with Metamizole sodium monohydrate use.\n\nCommon Side Effects:\n- Nausea: mild to moderate stomach upset.\n- Vomiting: occasional emesis after dosing.\n- Dizziness: transient light‑headedness.\n- Hypotension: occasional drop in blood pressure, especially with rapid intravenous administration.\n- Rash: mild skin erythema or itching.\n\nSerious or Rare Side Effects:\n- Agranulocytosis: severe reduction in white blood cells, requiring immediate medical attention.\n- Aplastic anemia: rare bone‑marrow failure.\n- Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.\n- Blood dyscrasias: abnormal blood cell counts.\n- Renal impairment: occasional acute kidney injury.

What precautions apply to Metamizole Sodium Monohydrate?

When prescribing or dispensing Nofebran, consider the following precautions.\n\n- Assess renal function: adjust use in patients with renal impairment.\n- Monitor blood counts: watch for early signs of agranulocytosis.\n- Avoid in known hypersensitivity: discontinue if allergic reactions occur.\n- Use caution in the elderly: increased sensitivity to hypotensive effects.\n- Store at ambient temperature: keep in the original pack, protect from moisture.

What does Metamizole Sodium Monohydrate interact with?

Metamizole sodium monohydrate may interact with several drug classes.\n\nMajor Interactions (Avoid):\n- Other pyrazolones: additive toxicity risk.\n- Anticoagulants: heightened bleeding tendency.\n- Concurrent NSAIDs: increased gastrointestinal adverse events.\n\nModerate Interactions (Monitor Closely):\n- ACE inhibitors: possible renal function changes.\n- Diuretics: monitor electrolyte balance.\n- CYP450 substrates: potential alteration of metabolism.

Frequently asked questions

What is Nofebran used for?+
Nofebran contains Metamizole sodium monohydrate, which is used to treat moderate to severe pain and to lower high fever when other antipyretics are insufficient. It is commonly prescribed for acute pain episodes, postoperative discomfort, and febrile conditions.
How does Metamizole sodium monohydrate work?+
Metamizole sodium monohydrate works by inhibiting cyclooxygenase enzymes and modulating prostaglandin synthesis, which reduces the production of substances that cause pain and fever. The precise mechanism is not completely understood, but the net effect is analgesia and antipyresis.
What is the usual dose of Nofebran?+
The appropriate dose of Nofebran is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and renal function. Dosage regimens can vary, and patients should follow the prescriber’s instructions without deviation.
Is Nofebran safe during pregnancy or breastfeeding?+
Safety data for Metamizole sodium monohydrate in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks with their healthcare provider before using Nofebran.
How do I order Nofebran from GNH USA?+
To order Nofebran, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.
How does Nofebran compare with other analgesics?+
Compared with traditional NSAIDs, Metamizole offers strong analgesic and antipyretic effects with a lower incidence of gastrointestinal irritation. Unlike opioids, it does not cause respiratory depression, but it carries a risk of rare blood‑cell disorders such as agranulocytosis, which requires monitoring.
What are the storage and handling requirements for Nofebran?+
Nofebran should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.
How is Nofebran administered?+
Nofebran is administered orally. The tablet or oral formulation should be swallowed whole with a glass of water, unless the prescriber provides specific instructions for crushing or mixing with food or liquid.
What are the most serious risks associated with Nofebran?+
The most serious risks include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe skin reactions such as Stevens‑Johnson syndrome. Early detection through regular blood‑count monitoring is essential to mitigate these rare but critical adverse events.
Who should not use Nofebran?+
Nofebran should be avoided in individuals with known hypersensitivity to Metamizole or other pyrazolones, patients with a history of blood‑cell disorders, and those who have experienced severe skin reactions to similar medications. Consultation with a healthcare professional is required before initiating therapy.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Oral Use
Manufacturer
Zentiva, K.S.
Origin
EU

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