GNH USA

Europe — EMA

Nofebran (Metamizole Sodium Monohydrate)

GNH USA supplies Nofebran (Metamizole Sodium), a non‑opioid analgesic for acute pain, post‑operative pain and fever.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole sodium, the active ingredient in Nofebran, is a non‑opioid analgesic presented as an injectable solution for intravenous use in the European market. It is employed to manage acute pain, post‑operative pain, fever and colic in adult patients requiring rapid symptom control.

GNH USA supplies Nofebran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and procurement teams throughout worldwide, with a focus on reliable cold‑chain logistics and regulatory compliance, and adheres to stringent quality standards for global distribution.

What is Metamizole Sodium Monohydrate used for?

Metamizole sodium is used as a non‑opioid analgesic and antipyretic for several acute conditions.

Acute pain: provides rapid relief of moderate to severe pain where opioid use is not desired. Post‑operative pain: reduces pain intensity after surgical procedures, facilitating early mobilization. Fever: lowers elevated body temperature in patients with high fever unresponsive to other antipyretics. Colic: alleviates visceral pain associated with gastrointestinal colic in adult patients.

What are the side effects of Metamizole Sodium Monohydrate?

Metamizole sodium may be associated with a range of adverse reactions, varying from mild to potentially life‑threatening.

Common Side Effects: - Hypotension - Nausea - Vomiting - Dizziness

Serious or Rare Side Effects: - Agranulocytosis (severe neutropenia) - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Anaphylactic shock

What precautions apply to Metamizole Sodium Monohydrate?

When using Metamizole sodium, several precautions should be observed to minimize risk.

Assess blood counts: monitor complete blood count regularly for signs of agranulocytosis. Check for allergies: avoid use in patients with known hypersensitivity to metamizole or related compounds. Renal and hepatic function: use with caution in patients with impaired kidney or liver function. Concurrent myelotoxic drugs: avoid combining with other agents that suppress bone marrow. Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Metamizole Sodium Monohydrate interact with?

Metamizole sodium can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid): - Other NSAIDs or COX inhibitors: increased risk of severe blood dyscrasias. - Myelotoxic agents (e.g., chemotherapy): additive bone‑marrow suppression. - Anticoagulants (e.g., warfarin): heightened bleeding tendency.

Moderate Interactions (Monitor Closely): - Diuretics: potential for electrolyte disturbances. - ACE inhibitors or ARBs: monitor renal function. - Lithium: possible alteration of serum lithium levels.

Frequently asked questions

What is Nofebran used for?+
Nofebran contains metamizole sodium and is indicated for the management of acute pain, post‑operative pain, high fever, and visceral pain such as colic. It is used in adult patients when rapid analgesic or antipyretic effect is required, particularly in hospital settings.
How does Metamizole sodium work?+
Metamizole sodium works by non‑selectively inhibiting cyclooxygenase enzymes COX‑1 and COX‑2, which reduces the production of prostaglandins that mediate pain and fever. The lowered prostaglandin levels produce analgesic and antipyretic effects, while the drug does not act on opioid receptors.
What is the usual dose of Nofebran?+
The dosage of Nofebran is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, and clinical response. Healthcare professionals adjust the dose and infusion rate according to standard medical guidelines and individual patient factors.
Is Nofebran safe in pregnancy or breastfeeding?+
Safety data for metamizole sodium during pregnancy and lactation are limited, and the product is generally used only when the potential benefit outweighs the risk. Clinicians should evaluate each case carefully and consider alternative therapies when possible.
How do I order Nofebran from GNH USA?+
To order Nofebran, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.
How does Nofebran compare with the main alternative drug or class?+
Nofebran (metamizole sodium) is a non‑opioid analgesic that offers rapid pain relief similar to other NSAIDs but with a distinct safety profile, notably a risk of agranulocytosis. Compared with opioid analgesics, it does not cause respiratory depression, while it may be preferred over some NSAIDs when gastrointestinal tolerance is a concern.
How should Nofebran be stored and handled?+
Nofebran should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. The product should be kept in its original packaging until use to maintain stability and sterility.
How is Nofebran administered?+
Nofebran is supplied as an injectable solution for intravenous administration. It is typically given by slow IV infusion under medical supervision, allowing the clinician to monitor the patient for any immediate adverse reactions during and after the infusion.
What are the most serious risks to watch for when using Nofebran?+
The most serious risks associated with Nofebran include agranulocytosis, which can lead to severe infections, life‑threatening skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, and anaphylactic shock. Prompt recognition of symptoms and immediate medical intervention are essential.
Who should not use Nofebran?+
Nofebran should be avoided in patients with known hypersensitivity to metamizole or other pyrazolone derivatives, those with a history of severe blood dyscrasias, and individuals with uncontrolled severe infections. Caution is also advised for patients with significant renal or hepatic impairment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Intravenous Use
Manufacturer
Zentiva, K.S.
Origin
EU

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