Nodoryl (Metamizole Sodium Monohydrate)

Metamizole Sodium, the active ingredient in Nodoryl, is a pyrazolone non‑opioid analgesic presented as an oral formulation for oral use. It provides analgesic and antipyretic effects for mild to moderate pain, postoperative discomfort, fever, and visceral colic in adult patients.

GNH USA supplies Nodoryl as a licensed, GDP‑compliant international pharmaceutical product to hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides regulatory documentation for import and distribution. Our global logistics network ensures timely delivery and product integrity across diverse markets.

Metamizole Sodium is employed in the management of pain and fever across several clinical situations.

- Mild to moderate pain: reduces discomfort in acute or chronic pain states. - Post‑operative pain: provides analgesia after surgical procedures. - Fever: lowers elevated body temperature associated with infection or inflammation. - Colic and visceral pain: alleviates spasm‑related abdominal discomfort. - Headache: offers relief for tension‑type or migraine‑associated pain.

Metamizole Sodium may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects: - Nausea: mild gastrointestinal upset. - Vomiting: occasional emesis. - Dizziness: transient light‑headedness. - Hypotension: mild blood pressure reduction. - Skin rash: mild erythematous reactions. - Leukopenia: reduced white blood cell count.

Serious or Rare Side Effects: - Agranulocytosis: severe neutropenia with infection risk. - Stevens‑Johnson syndrome: severe skin and mucosal reactions. - Hepatic failure: significant liver enzyme elevation. - Renal impairment: acute kidney injury.

Before prescribing Metamizole Sodium, clinicians should evaluate several safety considerations.

- Renal function: assess baseline kidney function and monitor during therapy. - Hepatic function: evaluate liver enzymes, especially in patients with pre‑existing disease. - Blood disorders: avoid use in individuals with a history of agranulocytosis or severe leukopenia. - Concomitant NSAIDs: limit combined use to reduce risk of gastrointestinal and renal adverse effects. - Pregnancy and lactation: use only if clearly necessary, as safety data are limited. - Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Metamizole Sodium can interact with other medicines, requiring attention to avoid harmful effects.

Major Interactions (Avoid): - Cytotoxic chemotherapy: may exacerbate neutropenia. - Anticoagulants: increased risk of bleeding. - Sulfonamide antibiotics: potential cross‑reactivity leading to hypersensitivity.

Moderate Interactions (Monitor Closely): - Diuretics: additive hypotensive effect. - ACE inhibitors: possible renal function alteration. - Other analgesics/NSAIDs: heightened gastrointestinal toxicity.