GNH USA

Europe — EMA

Nodoryl Dolo (Metamizole Sodium Monohydrate)

GNH USA supplies Nodoryl Dolo (Metamizole Sodium), a non‑opioid analgesic for mild to moderate pain and fever. Request a quote for global supply.

Metamizole Sodium Monohydrate

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What is Metamizole Sodium Monohydrate?

Metamizole sodium monohydrate, the active ingredient in Nodoryl Dolo, is a non‑opioid analgesic (pyrazolone derivative) presented as an oral dosage form for oral use. It is indicated for the relief of mild to moderate pain and for the reduction of fever in adult patients.

GNH USA supplies Nodoryl Dolo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

What is Metamizole Sodium Monohydrate used for?

Metamizole sodium is used as an analgesic and antipyretic, acting on pain and fever pathways.

Mild to moderate pain: provides effective analgesic relief in conditions such as musculoskeletal discomfort, postoperative pain, and dental pain. Fever: reduces elevated body temperature in acute febrile states. Visceral colic: alleviates spasm‑related discomfort such as biliary or renal colic.

What are the side effects of Metamizole Sodium Monohydrate?

Metamizole sodium may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects: - Nausea or vomiting - Dizziness or headache - Mild hypotension - Skin rash or itching

Serious or Rare Side Effects: - Agranulocytosis or severe leukopenia - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Anaphylactic reactions - Hepatic or renal impairment

What precautions apply to Metamizole Sodium Monohydrate?

When prescribing Metamizole sodium, several safety considerations should be observed.

Renal impairment: use with caution and monitor renal function. Hepatic disease: avoid or reduce dose in patients with liver dysfunction. History of blood disorders: contraindicated in patients with agranulocytosis or severe leukopenia. Concomitant NSAIDs or anticoagulants: increased risk of gastrointestinal bleeding. Pregnancy and lactation: safety not established; avoid unless benefit outweighs risk. Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

What does Metamizole Sodium Monohydrate interact with?

Metamizole sodium can interact with several medicines, requiring attention to avoid harmful effects.

Major Interactions (Avoid): - Cytotoxic agents (e.g., cyclophosphamide): risk of severe bone‑marrow suppression. - Anticoagulants (e.g., warfarin): increased bleeding tendency. - Other pyrazolones: additive toxicity.

Moderate Interactions (Monitor Closely): - ACE inhibitors: may enhance hypotensive effect. - Diuretics: may increase risk of renal impairment. - Lithium: may raise lithium plasma concentrations.

Frequently asked questions

What is Nodoryl Dolo used for?+
Nodoryl Dolo contains metamizole sodium, which is prescribed to relieve mild to moderate pain such as musculoskeletal, postoperative or dental pain, and to reduce fever in acute febrile conditions. It is a non‑opioid option used when other analgesics are unsuitable or insufficient.
How does metamizole sodium work?+
Metamizole sodium works by non‑selectively inhibiting cyclooxygenase enzymes, which lowers prostaglandin production. This reduces peripheral sensitisation of pain receptors and lowers the hypothalamic set‑point for temperature, providing both analgesic and antipyretic effects. Central mechanisms also contribute to its spasmolytic activity.
What is the usual dose of Nodoryl Dolo?+
The dose of Nodoryl Dolo is determined by the prescribing clinician based on the patient’s condition, age, weight, and renal or hepatic function. Healthcare professionals adjust the regimen to achieve effective pain or fever control while minimising risk.
Is Nodoryl Dolo safe in pregnancy or breastfeeding?+
Safety of metamizole sodium during pregnancy and lactation has not been established. It is generally avoided unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.
How do I order Nodoryl Dolo from GNH USA?+
To order Nodoryl Dolo, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.
How does Nodoryl Dolo compare with other analgesics?+
Compared with traditional NSAIDs, metamizole sodium offers analgesic and antipyretic effects with a lower incidence of gastrointestinal irritation but carries a rare risk of severe blood dyscrasias. Unlike opioids, it does not cause respiratory depression or dependence, making it a useful alternative for certain patient groups.
How should Nodoryl Dolo be stored?+
Nodoryl Dolo should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and sources of heat to maintain stability and potency throughout its shelf life.
How is Nodoryl Dolo administered?+
Nodoryl Dolo is administered orally. The tablet is swallowed whole with a glass of water, preferably after a meal to reduce gastrointestinal discomfort, unless the prescriber advises otherwise.
What are the most serious risks associated with Nodoryl Dolo?+
The most serious risks include agranulocytosis, a potentially life‑threatening drop in white blood cells, and severe skin reactions such as Stevens‑Johnson syndrome. Prompt medical attention is required if signs of infection, unexplained fever, or skin blistering develop while using the medication.
Who should not use Nodoryl Dolo?+
Nodoryl Dolo should be avoided in patients with a known hypersensitivity to metamizole or other pyrazolones, those with a history of agranulocytosis or severe leukopenia, and individuals with uncontrolled renal or hepatic impairment unless specifically directed by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Metamizole Sodium Monohydrate
Route
Oral Use
Manufacturer
Meditop Pharmaceutical Co. Ltd.
Origin
EU

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