Noctor (Diphenhydramine Hydrochloride)

Diphenhydramine Hydrochloride, the active ingredient in Noctor, is a first‑generation antihistamine presented as an oral dosage form for oral use. It treats allergic rhinitis, urticaria, pruritus and short‑term insomnia in appropriate patient groups.

GNH USA supplies Noctor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Diphenhydramine acts on histamine‑mediated allergic conditions and related symptoms. - Allergic rhinitis: reduces nasal congestion, sneezing and itching. - Urticaria and other allergic skin reactions: diminishes hives and associated itching. - Pruritus: provides relief from generalized itching. - Insomnia (short‑term use): induces drowsiness to aid sleep.

Adverse reactions may occur with diphenhydramine use.

Common Side Effects: - Drowsiness: feeling of sleepiness or reduced alertness. - Dry mouth: decreased salivary flow. - Blurred vision: temporary visual disturbance. - Constipation: reduced bowel movements. - Urinary retention: difficulty emptying the bladder. - Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects: - Tachycardia: rapid heart rate. - Anaphylaxis: severe allergic reaction with airway compromise. - Confusion or hallucinations: altered mental status. - Seizures: uncontrolled electrical activity in the brain. - Cardiac arrhythmias: irregular heart rhythm. - Severe skin reactions: such as Stevens‑Johnson syndrome.

When using Noctor, consider the following safety measures. - Pediatric use: follow prescriber guidance due to heightened sedation risk. - Operating machinery: avoid driving or using heavy equipment while impaired. - Glaucoma: anticholinergic effects may exacerbate intra‑ocular pressure. - Hepatic impairment: reduced metabolism may increase drug exposure. - Pregnancy and breastfeeding: consult a healthcare professional before use. - Store at below 25°C: keep in the original pack, protect from moisture.

Diphenhydramine may interact with several medicines.

Major Interactions (Avoid): - Alcohol: additive central nervous system depression. - MAO inhibitors: risk of hypertensive crisis. - Sedatives (e.g., benzodiazepines, opioids): enhanced sedation.

Moderate Interactions (Monitor Closely):\n- CYP2D6 inhibitors (e.g., fluoxetine): may increase diphenhydramine levels. - Antacids: can affect oral absorption. - Antihypertensives: possible additive hypotensive effect.