GNH USA

Europe — EMA

Noctis (Doxylamine Hydrogen Succinate)

GNH USA supplies Noctis (Doxylamine Hydrogen Succinate), a antihistamine for short-term insomnia, allergic rhinitis and common cold symptoms.

Doxylamine Hydrogen Succinate

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What is Doxylamine Hydrogen Succinate?

Doxylamine hydrogen succinate, the active ingredient in Noctis, is a antihistamine presented as an oral dosage form for oral use. It provides short‑term relief of insomnia and helps alleviate symptoms of allergic rhinitis and the common cold.

GNH USA supplies Noctis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Doxylamine Hydrogen Succinate used for?

Doxylamine hydrogen succinate acts on histamine H1 receptors to produce sedative and antiallergic effects, making it useful for several common conditions.

- Insomnia: short‑term assistance in falling asleep and maintaining sleep. - Allergic rhinitis: reduction of nasal congestion, itching, and sneezing. - Common cold: relief of runny nose, cough and sleep disturbance associated with cold symptoms.

What are the side effects of Doxylamine Hydrogen Succinate?

Adverse reactions may occur with doxylamine use and should be monitored.

Common Side Effects: - Drowsiness - Dry mouth - Dizziness - Headache

Serious or Rare Side Effects: - Anaphylaxis (severe allergic reaction) - Cardiac arrhythmia - Severe skin rash such as Stevens‑Johnson syndrome

What precautions apply to Doxylamine Hydrogen Succinate?

Use of Noctis requires attention to several safety considerations.

- Children under 12 years: avoid use unless specifically prescribed. - Elderly patients: start with the lowest effective dose and monitor for anticholinergic effects. - Concomitant CNS depressants: avoid or use with caution due to additive sedation. - Pregnancy and breastfeeding: safety not established; consult a healthcare professional. - Known hypersensitivity: do not use if allergic to doxylamine or related compounds. - Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

What does Doxylamine Hydrogen Succinate interact with?

Doxylamine may interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Alcohol: can intensify sedation and respiratory depression. - Central nervous system depressants (e.g., benzodiazepines, opioids): risk of profound drowsiness. - Monoamine oxidase inhibitors (MAOIs): may increase anticholinergic effects.

Moderate Interactions (Monitor Closely): - Anticholinergic drugs (e.g., atropine, tricyclic antidepressants): additive anticholinergic burden. - Selective serotonin reuptake inhibitors (SSRIs): monitor for increased sedation. - Antihypertensive agents: possible enhancement of blood pressure‑lowering effect.

Frequently asked questions

What is Noctis used for?+
Noctis contains doxylamine hydrogen succinate and is indicated for short‑term treatment of insomnia, relief of allergic rhinitis symptoms such as nasal congestion and sneezing, and alleviation of common cold symptoms that interfere with sleep.
How does doxylamine hydrogen succinate work?+
Doxylamine hydrogen succinate blocks histamine H1 receptors in the brain and peripheral tissues. This antagonism reduces histamine‑driven wakefulness and allergic inflammation, producing a sedative effect and decreasing nasal and respiratory symptoms.
What is the usual dose of Noctis?+
The appropriate dose of Noctis is determined by the prescribing healthcare professional based on the individual’s age, condition, and response. Typical adult dosing for insomnia is a single dose taken at bedtime, but exact amounts should follow the prescriber’s instructions.
Is Noctis safe during pregnancy or breastfeeding?+
Safety of doxylamine hydrogen succinate in pregnancy and lactation has not been definitively established. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Noctis.
How do I order Noctis from GNH USA?+
To order Noctis, submit an enquiry on the product page at gnh-usa.com specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does Noctis compare with the main alternative drug or class?+
The most common alternative to doxylamine is diphenhydramine, another first‑generation antihistamine. Both provide sedation and antiallergic effects, but doxylamine often has a slightly longer half‑life, which may result in more sustained sleep support. Side‑effect profiles are similar, though individual tolerance can vary.
How should Noctis be stored and handled?+
Noctis should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.
How is Noctis administered?+
Noctis is taken orally, usually with a glass of water. For insomnia, it is generally taken shortly before bedtime. If used for allergic rhinitis or cold symptoms, it can be taken with or without food as directed by a healthcare professional.
What are the most serious risks to watch for when using Noctis?+
Serious risks include severe allergic reactions such as anaphylaxis, cardiac arrhythmias, and rare but severe skin reactions like Stevens‑Johnson syndrome. If any signs of these conditions appear—such as difficulty breathing, rapid heartbeat, or widespread rash—seek immediate medical attention.
Who should not use Noctis?+
Noctis should be avoided by individuals with known hypersensitivity to doxylamine or other first‑generation antihistamines, children under 12 years of age unless specifically prescribed, pregnant or breastfeeding women without medical advice, and patients with severe hepatic impairment or uncontrolled narrow‑angle glaucoma.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Doxylamine Hydrogen Succinate
Route
Oral Use
Manufacturer
Biofarm Sp. Z O.O.
Origin
EU

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