Nocedan (Levocetirizine Dihydrochloride)

Levocetirizine dihydrochloride, the active ingredient in Nocedan, is an antihistamine presented as an oral tablet for oral use. It alleviates symptoms of allergic rhinitis and chronic idiopathic urticaria in adults and children when prescribed.

GNH USA supplies Nocedan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand. Our distribution network ensures timely delivery and reliable product traceability across multiple continents worldwide.

Levocetirizine is an antihistamine that reduces histamine‑mediated symptoms in allergic conditions.

Allergic rhinitis: relief of nasal congestion, sneezing, itching and rhinorrhea. Seasonal allergic rhinitis: symptom control during pollen‑driven allergy periods. Chronic idiopathic urticaria: reduction of wheal formation and itching.

Levocetirizine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects: - Drowsiness: mild sedation. - Dry mouth: reduced salivation. - Headache: mild cranial pain. - Nausea: upset stomach.

Serious or Rare Side Effects: - Angioedema: swelling of face, lips or throat. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Anaphylaxis: rapid, life‑threatening allergic response.

Before initiating levocetirizine therapy, certain precautions should be considered to ensure safe use.

- Assess renal function: dose adjustment may be needed in severe renal impairment. - Avoid in known hypersensitivity: discontinue if allergic reaction occurs. - Caution with hepatic impairment: monitor liver function tests. - Monitor sedation: advise patients not to operate machinery if drowsiness occurs. - Pregnancy and lactation: use only if clearly needed after medical evaluation. - Store at room temperature: keep in the original container, protect from moisture.

Levocetirizine can interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid): - Ketoconazole: may increase levocetirizine plasma concentrations. - Erythromycin: can raise systemic exposure leading to heightened side effects. - Ritonavir: strong CYP3A4 inhibition may elevate drug levels.

Moderate Interactions (Monitor Closely): - Alcohol: additive central nervous system depression may increase drowsiness. - Other CNS depressants: such as benzodiazepines, may enhance sedation. - Theophylline: may reduce antihistaminic effect.