GNH USA

Europe — EMA

No-Spa (Drotaverine Hydrochloride)

GNH USA supplies No-Spa (Drotaverine Hydrochloride), a antispasmodic for abdominal cramping, menstrual pain and biliary colic. Request a quote for supply.

Drotaverine Hydrochloride

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What is Drotaverine Hydrochloride?

Drotaverine Hydrochloride, the active ingredient in No-Spa, is an antispasmodic (smooth muscle relaxant) presented as an oral tablet for oral use. It relieves painful smooth‑muscle spasms in the gastrointestinal, biliary, urinary and uterine systems, helping patients with abdominal cramping, dysmenorrhea and related conditions.

GNH USA supplies No-Spa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance, regulatory compliance and reliable global logistics. The company maintains stringent manufacturing standards and provides comprehensive documentation for import and distribution.

What is Drotaverine Hydrochloride used for?

Drotaverine Hydrochloride is used to relieve smooth‑muscle spasm in several abdominal and pelvic conditions. - Abdominal cramping: reduction of painful intestinal muscle contractions. - Menstrual pain (dysmenorrhea): alleviation of uterine cramps during menstruation. - Biliary colic: easing of gall‑bladder muscle spasm associated with bile flow obstruction. - Urinary tract spasm: relaxation of bladder neck and ureteral smooth muscle to improve discomfort. - Gastrointestinal smooth‑muscle spasm: relief of spasmodic episodes in the stomach and intestines.

What are the side effects of Drotaverine Hydrochloride?

Drotaverine Hydrochloride may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects: - Nausea: mild stomach upset. - Dizziness: transient light‑headedness. - Dry mouth: reduced salivation. - Headache: mild to moderate pain. - Hypotension: temporary low blood pressure. - Fatigue: feeling of tiredness.

Serious or Rare Side Effects: - Allergic reactions: rash, itching, swelling. - Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Hepatic enzyme elevation: signs of liver irritation. - Cardiac arrhythmia: irregular heartbeat. - Blood disorders: neutropenia or thrombocytopenia.

What precautions apply to Drotaverine Hydrochloride?

When prescribing Drotaverine Hydrochloride, clinicians should consider several safety measures to minimize risk. - Assess renal function: adjust use in severe renal impairment. - Monitor blood pressure: watch for symptomatic hypotension. - Avoid in known hypersensitivity: discontinue if allergic signs appear. - Use caution in pregnancy: safety not established, weigh benefits and risks. - Review concomitant medications: consider additive effects with other antispasmodics. - Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

What does Drotaverine Hydrochloride interact with?

Drotaverine Hydrochloride can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid): - Potent CYP3A4 inhibitors: may increase drotaverine plasma concentrations. - Concurrent use with other antispasmodics: risk of excessive smooth‑muscle relaxation. - MAO inhibitors: potential for severe hypotension.

Moderate Interactions (Monitor Closely): - Antihypertensive agents: additive blood‑pressure‑lowering effect. - Alcohol: may enhance dizziness and hypotension. - Antihistamines: possible increase in sedation or drowsiness.

Frequently asked questions

What conditions is No-Spa used to treat?+
No-Spa, containing drotaverine hydrochloride, is indicated for the relief of smooth‑muscle spasms that cause abdominal cramping, menstrual pain (dysmenorrhea), biliary colic, urinary tract spasm and other gastrointestinal smooth‑muscle disorders. It helps reduce the intensity of painful contractions in these areas.
How does Drotaverine Hydrochloride work?+
Drotaverine Hydrochloride works by inhibiting the enzyme phosphodiesterase‑4, which raises intracellular cyclic AMP levels in smooth‑muscle cells. The increase in cAMP reduces calcium entry into the cells, leading to relaxation of the muscle fibers and a decrease in spasm without significant anticholinergic activity.
What is the usual dose of No-Spa?+
The appropriate dose of No-Spa is determined by a qualified healthcare professional based on the individual’s condition, age, weight and overall health. Prescribers set the dosage and frequency according to clinical guidelines and patient response, and patients should follow the prescribed regimen exactly.
Is No-Spa safe during pregnancy or breastfeeding?+
Safety data for drotaverine hydrochloride in pregnancy and lactation are limited, and the product is generally classified as having an unknown pregnancy category. Healthcare providers should evaluate the potential benefits against possible risks before prescribing No‑Spa to pregnant or nursing women.
How do I order No-Spa from GNH USA?+
To order No‑Spa, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.
How does No-Spa compare with other antispasmodics such as hyoscine?+
No‑Spa (drotaverine) differs from anticholinergic agents like hyoscine by acting primarily through phosphodiesterase‑4 inhibition rather than blocking muscarinic receptors. This mechanism often results in fewer anticholinergic side effects such as dry mouth or blurred vision, while providing comparable relief of smooth‑muscle spasm.
How should No-Spa be stored and handled?+
No‑Spa tablets should be stored at room temperature, below 25 °C, in their original packaging to protect them from moisture and direct sunlight. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.
How is No-Spa administered?+
No‑Spa is administered orally, typically as a tablet that is swallowed with water. The exact method of administration, including whether it should be taken with or without food, is determined by the prescribing clinician based on the patient’s specific therapeutic needs.
What are the most serious risks associated with No-Spa?+
Serious but rare risks of No‑Spa include severe allergic reactions such as rash, swelling or Stevens‑Johnson syndrome, significant drops in blood pressure, cardiac arrhythmias, liver enzyme elevations and blood‑cell abnormalities like neutropenia. Patients should seek immediate medical attention if any of these symptoms occur.
Who should not use No-Spa?+
No‑Spa should be avoided in individuals with known hypersensitivity to drotaverine or any of its excipients, in patients with severe renal impairment without dose adjustment, and in those taking contraindicated medications such as potent CYP3A4 inhibitors or other antispasmodics unless supervised by a physician.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Drotaverine Hydrochloride
Route
Oral Use
Manufacturer
Opella Healthcare Poland Sp. Z O.O.
Origin
EU

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