GNH USA

Europe — EMA

No-Spa (Drotaverine Hydrochloride)

GNH USA supplies No-Spa (Drotaverine Hydrochloride), a phosphodiesterase‑4 inhibitor for smooth muscle spasm, abdominal pain and biliary colic.

Drotaverine Hydrochloride

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What is Drotaverine Hydrochloride?

Drotaverine Hydrochloride, the active ingredient in No-Spa, is a phosphodiesterase-4 inhibitor presented as an injectable solution for intramuscular and intravenous use. It relieves smooth‑muscle spasm and associated pain in adult patients.

GNH USA supplies No-Spa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Drotaverine Hydrochloride used for?

Drotaverine Hydrochloride is an antispasmodic used to manage conditions involving smooth‑muscle contraction.

- Smooth muscle spasm: provides rapid relief of involuntary muscle contraction. - Abdominal pain: reduces pain linked to gastrointestinal spasm. - Biliary colic: alleviates pain caused by gallbladder muscle contraction. - Menstrual cramps: eases dysmenorrhea by relaxing uterine smooth muscle.

What are the side effects of Drotaverine Hydrochloride?

Adverse reactions may occur with any pharmacologic agent and should be monitored by the prescribing clinician.

Common Side Effects: - Dizziness - Nausea - Headache - Flushing

Serious or Rare Side Effects: - Anaphylactic reaction - Severe hypotension - Hepatic enzyme elevation

What precautions apply to Drotaverine Hydrochloride?

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential complications.

- Pregnancy: safety not established; use only if clearly needed. - Breastfeeding: unknown; weigh benefits against potential risks. - Renal impairment: consider dose adjustment and monitor renal function. - Cardiovascular disease: caution due to vasodilatory properties. - Drug interactions: review concomitant medications for possible interactions. - Store below 25°C: keep in original container, protect from light and moisture.

What does Drotaverine Hydrochloride interact with?

Drotaverine may interact with other medicines that affect vascular tone or metabolism.

Major Interactions (Avoid): - Co‑administration with other potent vasodilators: risk of severe hypotension. - Combination with anticholinergic agents: may diminish antispasmodic efficacy.

Moderate Interactions (Monitor Closely): - Non‑steroidal anti‑inflammatory drugs (NSAIDs): may increase gastrointestinal irritation. - Antihistamines: may enhance sedative effects. - Beta‑blockers: may potentiate hypotensive response.

Frequently asked questions

What is No-Spa used for?+
No-Spa contains drotaverine hydrochloride and is employed to relieve smooth‑muscle spasm and the associated pain that can occur in conditions such as abdominal discomfort, biliary colic, and menstrual cramps. It is administered by injection to provide rapid symptom control in adult patients.
How does drotaverine hydrochloride work?+
Drotaverine blocks phosphodiesterase‑4 enzymes, which raises intracellular cyclic AMP levels. The increase in cAMP leads to relaxation of smooth muscle cells and vasodilation, thereby reducing spasm and improving blood flow in the affected area.
What is the usual dose of No-Spa?+
The specific dose of No‑Spa is determined by the prescribing clinician based on the patient’s condition, weight, age, and response to therapy. Healthcare professionals tailor the regimen to achieve optimal relief while minimizing potential adverse effects.
Is No-Spa safe during pregnancy or breastfeeding?+
Safety data for drotaverine during pregnancy and lactation are limited. It should only be used when the potential benefit justifies the possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.
How do I order No-Spa from GNH USA?+
To request No‑Spa, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.
How does No-Spa compare with other antispasmodics?+
Compared with anticholinergic agents, drotaverine acts via phosphodiesterase inhibition rather than muscarinic blockade, which often results in fewer anticholinergic side effects such as dry mouth or blurred vision. Its rapid onset after injection can be advantageous in acute spasm situations.
How should No-Spa be stored and handled?+
Store No‑Spa below 25 °C in its original packaging, protecting it from light and moisture. Avoid freezing the product and ensure that any reconstituted solution is used within the time frame recommended by the manufacturer.
How is No-Spa administered to patients?+
No‑Spa is supplied as an injectable solution for intramuscular or intravenous administration. The route, injection site, and infusion rate are selected by the treating clinician according to the clinical situation and patient tolerance.
What are the most serious risks to watch for?+
Serious adverse events, although rare, include anaphylactic reactions, severe hypotension and significant elevations in liver enzymes. Immediate medical attention is required if any signs of allergic reaction, sudden drop in blood pressure, or jaundice develop.
Who should not use No-Spa?+
Patients with known hypersensitivity to drotaverine or any component of the formulation should avoid No‑Spa. Caution is also advised for individuals with severe cardiovascular disease, uncontrolled hypertension, or significant hepatic impairment, and the drug should be used only under medical supervision in these groups.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Drotaverine Hydrochloride
Route
Intramuscular Use , Intravenous Use
Manufacturer
Opella Healthcare Romania Srl
Origin
EU

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