GNH USA

Europe — EMA

No-Spa (Drotaverine Hydrochloride)

GNH USA supplies No-Spa (Drotaverine Hydrochloride), a phosphodiesterase inhibitor antispasmodic for abdominal, biliary and renal colic, dysmenorrhea

Drotaverine Hydrochloride

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What is Drotaverine Hydrochloride?

Drotaverine Hydrochloride, the active ingredient in No-Spa, is a phosphodiesterase inhibitor (smooth muscle relaxant) presented as an injectable solution for intramuscular and intravenous use. It relieves abdominal and visceral smooth‑muscle spasm, biliary colic, renal colic, dysmenorrhea and uterine spasm.

GNH USA supplies No-Spa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Drotaverine Hydrochloride used for?

Drotaverine Hydrochloride is an antispasmodic that relaxes smooth muscle in the gastrointestinal, biliary and urinary tracts. - Abdominal colic: reduces intensity and duration of visceral pain. - Biliary colic: alleviates gallbladder spasm and associated discomfort. - Renal colic: eases ureteral smooth‑muscle spasm, facilitating stone passage. - Dysmenorrhea: diminishes uterine muscle contractions and menstrual pain. - Uterine spasm (post‑operative): facilitates relaxation of uterine smooth muscle after surgery.

What are the side effects of Drotaverine Hydrochloride?

Adverse reactions may occur with any injectable medication.

Common Side Effects: - Injection site pain. - Mild hypotension. - Nausea. - Dizziness.

Serious or Rare Side Effects: - Anaphylactic or severe allergic reaction. - Profound hypotension. - Cardiac arrhythmia. - Hepatic dysfunction.

What precautions apply to Drotaverine Hydrochloride?

Use of No‑Spa requires careful clinical assessment. - Cardiovascular assessment: evaluate blood pressure and heart status before administration. - Monitor blood pressure: observe for hypotensive episodes during and after injection. - Hepatic impairment: use with caution in patients with liver disease. - Hypersensitivity: avoid in individuals with known allergy to drotaverine or excipients. - Do not mix with other injectable solutions unless compatibility is confirmed. - Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

What does Drotaverine Hydrochloride interact with?

Drotaverine may interact with other medicines affecting vascular tone or metabolism.

Major Interactions (Avoid): - Concomitant use with potent vasodilators (e.g., nitroglycerin) may cause severe hypotension. - Co‑administration with other antispasmodics can lead to additive smooth‑muscle relaxation.

Moderate Interactions (Monitor Closely): - Beta‑blockers: may blunt compensatory tachycardia during hypotension. - CYP450 inhibitors: could increase drotaverine plasma levels. - Diuretics: may enhance the risk of low blood pressure.

Frequently asked questions

What is No‑Spa used for?+
No‑Spa contains drotaverine hydrochloride, an antispasmodic indicated for the relief of smooth‑muscle spasm in abdominal and visceral colic, biliary colic, renal colic, dysmenorrhea and uterine spasm. It is administered by injection under medical supervision.
How does drotaverine work?+
Drotaverine selectively inhibits phosphodiesterase‑4, which raises intracellular cyclic AMP levels in smooth‑muscle cells. The increased cAMP reduces calcium entry, leading to relaxation of visceral smooth muscle and alleviation of spasm.
What is the usual dose of No‑Spa?+
The specific dose and frequency are determined by the prescribing clinician based on the indication, patient weight, renal and hepatic function, and the chosen route of administration. No‑Spa is supplied as an injectable solution for intramuscular or intravenous use.
Is No‑Spa safe during pregnancy or breastfeeding?+
Safety data for drotaverine in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.
How do I order No‑Spa from GNH USA?+
To place an order, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.
How does No‑Spa compare with other antispasmodic drugs?+
Compared with anticholinergic agents such as hyoscine or papaverine, drotaverine has a selective phosphodiesterase‑4 inhibition profile, which may result in fewer anticholinergic side effects like dry mouth or blurred vision. Choice of therapy depends on the specific indication, patient tolerance and physician preference.
How should No‑Spa be stored and handled?+
No‑Spa must be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Vials should remain in their original packaging until use, and any unused solution should be discarded according to local regulations.
How is No‑Spa administered?+
No‑Spa is supplied as a sterile injectable solution and can be given either intramuscularly or intravenously by a qualified healthcare professional. The injection site should be prepared aseptically, and the solution should be used promptly after reconstitution if required.
What are the most serious risks to watch for with No‑Spa?+
Serious but uncommon adverse reactions include anaphylactic or severe allergic responses, profound hypotension, cardiac arrhythmias, and hepatic dysfunction. Patients should be monitored for signs of these events, and treatment should be stopped immediately if they occur.
Who should not use No‑Spa?+
No‑Spa is contraindicated in individuals with known hypersensitivity to drotaverine or any excipients in the formulation. Caution is advised in patients with severe cardiovascular disease, uncontrolled hypertension, or significant liver impairment, and it should be avoided where the risk of severe hypotension outweighs therapeutic benefit.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Drotaverine Hydrochloride
Route
Intramuscular Use , Intravenous Use
Manufacturer
Opella Healthcare France Sas
Origin
EU

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