GNH USA

Europe — EMA

No-Spa Comfort (Drotaverine Hydrochloride)

GNH USA supplies No-Spa Comfort (Drotaverine Hydrochloride), an antispasmodic for abdominal cramps, biliary colic and dysmenorrhea. Request a quote.

Drotaverine Hydrochloride

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What is Drotaverine Hydrochloride?

Drotaverine Hydrochloride, the active ingredient in No-Spa Comfort, is an antispasmodic (smooth muscle relaxant) presented as an oral tablet for systemic use. It relieves spasms of the gastrointestinal tract, biliary system, urinary tract and uterine muscle, helping to reduce pain associated with these conditions.

GNH USA supplies No-Spa Comfort as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

What is Drotaverine Hydrochloride used for?

Drotaverine Hydrochloride acts as a smooth‑muscle relaxant and is used for several spasm‑related conditions.

- Abdominal and gastrointestinal smooth‑muscle spasm: alleviates cramping and improves bowel comfort. - Biliary colic: reduces gall‑bladder muscle spasms and associated pain. - Menstrual cramps (dysmenorrhea): eases uterine contractions and menstrual pain. - Urinary tract spasm: relaxes bladder smooth muscle to relieve discomfort. - Renal colic: diminishes ureteral spasm and facilitates stone passage.

What are the side effects of Drotaverine Hydrochloride?

Drotaverine Hydrochloride may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects: - Dizziness - Headache - Nausea - Dry mouth

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) - Marked hypotension - Cardiac arrhythmia

What precautions apply to Drotaverine Hydrochloride?

When using Drotaverine Hydrochloride, consider the following precautions to ensure safe therapy.

- Pregnancy: safety not established; avoid unless benefits outweigh risks. - Breastfeeding: unknown; assess risk before use. - Renal impairment: use with caution and monitor renal function. - Elderly patients: may be more sensitive to hypotensive effects; start at lower dose if applicable. - Concomitant medications: review for potential interactions before initiating therapy. - Store at ambient temperature (below 25°C): keep in original packaging, protect from moisture.

What does Drotaverine Hydrochloride interact with?

Drotaverine Hydrochloride can interact with other medicines; awareness of major and moderate interactions helps prevent adverse events.

Major Interactions (Avoid): - Strong CYP3A4 inhibitors: may increase drotaverine plasma levels. - Anticholinergic agents: additive antispasmodic effect can cause excessive smooth‑muscle relaxation. - Antihistamines with sedative properties: may enhance dizziness.

Moderate Interactions (Monitor Closely): - NSAIDs: combined use may increase gastrointestinal discomfort. - Diuretics: additive hypotensive effect; monitor blood pressure. - Antihypertensive drugs: may potentiate blood pressure lowering.

Frequently asked questions

What is No-Spa Comfort used for?+
No-Spa Comfort contains drotaverine hydrochloride, an antispasmodic that is used to relieve smooth‑muscle spasms in the gastrointestinal tract, biliary system, urinary tract and uterus. It is commonly prescribed for abdominal cramps, biliary colic, menstrual pain, urinary tract spasm and renal colic.
How does drotaverine work?+
Drotaverine works by selectively inhibiting phosphodiesterase‑4, which raises intracellular cyclic AMP levels in smooth‑muscle cells. The increased cAMP reduces calcium entry, leading to relaxation of smooth muscle. Its additional calcium‑antagonist activity further enhances the antispasmodic effect.
What is the usual dose of No-Spa Comfort?+
The dosage of No-Spa Comfort is determined by a qualified healthcare professional based on the individual’s condition, age, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical advice.
Is No-Spa Comfort safe during pregnancy or breastfeeding?+
Safety data for drotaverine during pregnancy and lactation are limited. The product is classified as pregnancy category unknown, so it should only be used if the potential benefit justifies the potential risk. Breastfeeding mothers should consult their physician before use.
How do I order No-Spa Comfort from GNH USA?+
To order No-Spa Comfort, submit an enquiry on the product page at gnh-usa.com, specifying the required quantity. GNH USA supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details and any required import documentation.
How does No-Spa Comfort compare with other antispasmodics?+
Compared with hyoscine butylbromide, another common antispasmodic, drotaverine has a distinct mechanism—selective PDE‑4 inhibition and calcium antagonism—rather than anticholinergic activity. This can result in fewer anticholinergic side effects such as dry mouth or blurred vision, while providing comparable relief of smooth‑muscle spasm.
How should No-Spa Comfort be stored and handled?+
Store No-Spa Comfort at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and keep them out of reach of children.
How is No-Spa Comfort administered?+
No-Spa Comfort is taken orally. The tablet should be swallowed whole with a glass of water, preferably after a meal unless otherwise directed by a healthcare professional.
What are the most serious risks associated with No-Spa Comfort?+
The most serious risks include severe allergic reactions such as anaphylaxis, marked hypotension, and rare cardiac arrhythmias. Patients experiencing signs of these conditions—such as rash, swelling, sudden drop in blood pressure, or irregular heartbeat—should seek immediate medical attention.
Who should not use No-Spa Comfort?+
No-Spa Comfort should be avoided in individuals with known hypersensitivity to drotaverine or any excipients, in patients with severe hypotension, and in those for whom antispasmodic therapy is contraindicated. Caution is also advised for patients with significant cardiac, hepatic or renal impairment.
Information provided on this page is for educational use by procurement and clinical professionals. Always consult a licensed healthcare provider for medical advice and prescribing decisions. GNH USA supplies this product subject to applicable regulatory and licensing requirements.
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Product details

Drug
Drotaverine Hydrochloride
Route
Oral Use
Manufacturer
Opella Healthcare Poland Sp. Z O.O.
Origin
EU

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