Nizoral (Ketoconazole)

Ketoconazole, the active ingredient in Nizoral, is a azole antifungal presented as a topical formulation for skin use. It is employed to treat fungal skin infections such as tinea corporis, tinea cruris, tinea pedis, seborrheic dermatitis and pityriasis versicolor in patients requiring topical therapy.

GNH USA supplies Nizoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoconazole is an azole antifungal that acts on dermatophyte and yeast infections of the skin. - Tinea corporis: reduces fungal growth and clears the ring‑shaped rash. - Tinea cruris: alleviates itching and erythema in the groin area. - Tinea pedis: eliminates foot fungus and prevents recurrence. - Seborrheic dermatitis: controls flaking and redness on scalp and face. - Pityriasis versicolor: restores normal skin pigmentation by eradicating Malassezia species.

Topical ketoconazole may cause local skin reactions.

Common Side Effects: - Burning sensation at the application site - Itching or pruritus - Mild irritation or redness - Dryness or peeling of the skin - Contact dermatitis - Stinging feeling after application

Serious or Rare Side Effects: - Severe allergic reaction (anaphylaxis) - Stevens‑Johnson syndrome or toxic epidermal necrolysis - Extensive swelling or edema of the treated area - Widespread rash or blistering - Persistent severe irritation requiring medical attention

Before using Nizoral, consider the following safety measures. - Avoid use on broken or inflamed skin: apply only to intact areas. - Do not apply near eyes, mouth or mucous membranes: risk of irritation. - Discontinue if severe irritation or allergic reaction occurs: seek medical advice. - Pregnant or breastfeeding individuals should consult a healthcare professional before use. - Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Ketoconazole topical has limited systemic absorption, but certain interactions should be noted.

Major Interactions (Avoid): - Concurrent use with other topical antifungals containing the same active ingredient: may increase irritation risk. - Application over large areas combined with systemic azole therapy: could enhance systemic exposure.

Moderate Interactions (Monitor Closely): - Use with corticosteroid creams: may mask signs of infection. - Use with skin irritants or harsh soaps: could exacerbate local reactions. - Systemic medications metabolized by CYP450 enzymes: monitor if extensive skin application leads to measurable absorption.