Nizoral (Ketoconazole)

Ketoconazole, the active ingredient in Nizoral, is an imidazole antifungal presented as a topical formulation for skin use. It treats fungal infections of the skin and scalp in both adults and children.\n\nGNH India supplies Nizoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoconazole is used topically to treat fungal skin conditions and related disorders.\n\nSeborrheic dermatitis: reduces inflammation and yeast overgrowth on the scalp and face.\nDandruff (pityriasis capitis): controls Malassezia species causing flaking and itching.\nTinea corporis: clears dermatophyte infection of the body skin.\nTinea cruris: treats fungal infection of the groin area.\nCutaneous candidiasis: eliminates Candida species on moist skin surfaces.

Ketoconazole may cause local skin reactions when applied.\n\nCommon Side Effects:\n- Itching or pruritus\n- Burning sensation at the application site\n- Redness or erythema\n- Dryness or scaling of the skin\n- Irritation or stinging\n- Mild contact dermatitis\n\nSerious or Rare Side Effects:\n- Allergic reaction with swelling or hives\n- Severe skin rash such as Stevens‑Johnson syndrome\n- Photosensitivity leading to exaggerated sunburn\n- Systemic liver toxicity (rare with topical use)\n- Extensive contact dermatitis\n- Secondary bacterial infection of the treated area

When using topical ketoconazole, consider the following precautions.\n\nPregnancy: safety not established; consult a healthcare professional before use.\nBreastfeeding: unknown safety; weigh benefits against potential risks.\nAge: use with caution in children under 12 years of age.\nSkin condition: avoid application on broken, inflamed, or ulcerated skin.\nDrug interactions: concurrent use of other topical agents may increase systemic absorption.\nStore at room temperature: keep in the original container, protect from moisture and light.

Ketoconazole can interact with other medicines, especially when systemic absorption occurs.\n\nMajor Interactions (Avoid):\n- Oral antifungals: concurrent use may raise systemic ketoconazole levels.\n- Strong CYP3A4 inhibitors: may increase ketoconazole exposure if absorbed.\n- Topical corticosteroids: may alter skin barrier and enhance absorption.\n\nModerate Interactions (Monitor Closely):\n- Alcohol: may increase risk of liver effects with systemic absorption.\n- Other topical agents: combined use can cause irritation or increased absorption.\n- Phototoxic drugs: may heighten photosensitivity reactions.