Nizoral (Ketoconazole)

Ketoconazole, the active ingredient in Nizoral, is an imidazole antifungal presented as a topical formulation for skin application. It treats fungal skin conditions such as seborrheic dermatitis, tinea infections, and pityriasis versicolor in both adults and children.

GNH USA supplies Nizoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoconazole is used to manage fungal skin disorders by inhibiting the growth of dermatophytes and yeasts. - Seborrheic dermatitis: reduces scaling, redness and itching on the scalp and face. - Tinea corporis (ringworm): clears lesions and prevents spread. - Tinea cruris (jock itch): relieves itching and resolves rash. - Tinea pedis (athlete's foot): eliminates foot fungus and reduces discomfort. - Pityriasis versicolor: restores normal skin pigmentation. - Dandruff: controls flaking and scalp irritation.

Topical ketoconazole may cause local skin reactions, most of which are mild and reversible.

Common Side Effects: - Burning sensation at the application site. - Itching or pruritus. - Redness or erythema. - Dryness or peeling of the skin. - Stinging or tingling. - Mild irritation.

Serious or Rare Side Effects: - Severe allergic reaction (e.g., angioedema, anaphylaxis). - Stevens‑Johnson syndrome or toxic epidermal necrolysis. - Contact dermatitis. - Significant swelling or blistering. - Systemic absorption leading to hepatic toxicity (rare). - Persistent or worsening skin infection.

Before using ketoconazole topical formulation, consider the following safety measures. - Pregnancy: consult a healthcare professional before use. - Breastfeeding: discuss potential risks with a physician. - Age: use with caution in children under 12 years. - Skin integrity: avoid application on broken or inflamed skin. - Concomitant topical agents: do not combine with other antifungal or irritant creams without medical advice. - Store at room temperature: keep in the original container, protect from moisture and light.

Ketoconazole can interact with other medications, affecting safety or efficacy.

Major Interactions (Avoid): - Oral ketoconazole: increased systemic exposure may raise risk of hepatotoxicity. - Systemic azole antifungals: additive inhibition of fungal enzymes can cause toxicity. - Topical corticosteroids: may mask infection signs and delay healing.

Moderate Interactions (Monitor Closely): - Warfarin: monitor INR as ketoconazole may enhance anticoagulant effect. - Rifampin: may reduce ketoconazole efficacy by inducing metabolism. - Antihistamines: monitor for increased sedation when used together.