Nizoral (Ketoconazole)

Ketoconazole, the active ingredient in Nizoral, is an azole antifungal presented as a topical formulation for skin use. It treats fungal infections such as tinea corporis, tinea cruris, tinea pedis, seborrheic dermatitis and pityriasis versicolor in adults and children.

GNH USA supplies Nizoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoconazole is an azole antifungal that interferes with fungal cell membrane synthesis, making it effective for a range of superficial mycoses.

- Tinea corporis: reduces lesion size and clears infection on body skin. - Tinea cruris: alleviates itching and eliminates fungal growth in the groin area. - Tinea pedis: treats athlete's foot by eradicating dermatophytes on the feet. - Seborrheic dermatitis: controls flaking and redness on scalp and face. - Pityriasis versicolor: restores normal skin pigmentation by eliminating Malassezia species.

Ketoconazole may cause local skin reactions when applied topically.

Common Side Effects: - Itching: mild to moderate sensation at the application site. - Burning: transient heat sensation during or after use. - Redness: localized erythema around the treated area. - Dryness: skin may feel less moisturized. - Irritation: mild discomfort or stinging. - Scaling: flaking of the outer skin layer.

Serious or Rare Side Effects: - Contact dermatitis: severe allergic skin reaction requiring medical attention. - Severe skin irritation: extensive redness or swelling. - Systemic absorption leading to liver enzyme abnormalities (rare with topical use). - Allergic reactions: hives, swelling of face or throat. - Stevens‑Johnson syndrome: rare but life‑threatening skin disorder. - Photosensitivity: increased sensitivity to sunlight.

When using topical ketoconazole, observe the following safety measures.

- Avoid application on broken skin: limit use to intact epidermis. - Do not use with occlusive dressings: may increase drug absorption. - Discontinue if severe irritation occurs: seek medical advice. - Avoid use in patients with known ketoconazole hypersensitivity: risk of allergic reaction. - Store at room temperature below 25°C: keep in the original pack, protect from moisture and light.

Ketoconazole can interact with other topical agents; consider the following.

Major Interactions (Avoid): - Concurrent use of oral ketoconazole: may increase systemic exposure. - Co‑application with other azole antifungals: risk of additive irritation. - Use with potent corticosteroid creams: may mask infection signs. - Use with photosensitizing agents: increased risk of phototoxicity.

Moderate Interactions (Monitor Closely): - Use with topical retinoids: may increase skin irritation. - Use with products containing alcohol: may cause excessive dryness.