Nizoral (Ketoconazole)

Ketoconazole, the active ingredient in Nizoral, is an azole antifungal presented as a topical formulation for skin use. It treats fungal skin infections such as dermatophyte infections, seborrheic dermatitis, and pityriasis versicolor in adults and children.

GNH USA supplies Nizoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Ketoconazole is an azole antifungal that targets fungal skin conditions. - Dermatophyte infections: reduces fungal growth and clears skin lesions. - Seborrheic dermatitis: alleviates scaling and erythema on the scalp and face. - Pityriasis versicolor: eliminates Malassezia species and restores normal skin pigmentation.

Topical ketoconazole may cause local or systemic adverse reactions, although most are mild.

Common Side Effects: - Skin irritation: redness, itching or burning at the application site. - Dryness: localized skin dryness or flaking. - Pruritus: mild itching. - Contact dermatitis: allergic skin reaction.

Serious or Rare Side Effects: - Hepatotoxicity: rare systemic absorption leading to liver enzyme elevation. - Severe allergic reaction: anaphylaxis or angioedema. - Stevens‑Johnson syndrome: extremely rare severe skin reaction.

When using topical ketoconazole, certain precautions should be observed to ensure safety and effectiveness. - Assess skin integrity: avoid application on broken or inflamed skin. - Limit area: restrict use to the prescribed body surface area. - Duration: do not exceed the treatment period recommended by the prescriber. - Concomitant therapy: inform healthcare provider of other topical or systemic antifungals. - Pregnancy and lactation: discuss risks with a healthcare professional before use. - Store at ambient temperature: keep below 25°C in the original container, protect from moisture and direct sunlight.

Ketoconazole can interact with other medicines, especially when systemic absorption occurs.

Major Interactions (Avoid): - Systemic azoles: concurrent use may increase risk of hepatotoxicity. - CYP3A4 substrates: strong inhibitors may raise plasma levels of drugs metabolized by this enzyme. - Warfarin: may potentiate anticoagulant effect.

Moderate Interactions (Monitor Closely): - Topical corticosteroids: may enhance skin irritation. - Antihistamines: monitor for increased sedation if systemic absorption occurs. - Oral contraceptives: may reduce efficacy; advise alternative contraception.