Nizoral (Ketoconazole)

Ketoconazole, the active ingredient in Nizoral, is an imidazole antifungal presented as a topical formulation for skin use. It treats a variety of superficial fungal infections in adults and children.

GNH USA supplies Nizoral as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality and regulatory compliance.

Ketoconazole is used topically to treat fungal skin conditions by targeting dermatophyte and yeast infections.

- Athlete's foot (tinea pedis): reduces itching and clears infection - Jock itch (tinea cruris): alleviates redness and eliminates fungal growth - Ringworm (tinea corporis): promotes healing of circular lesions - Seborrheic dermatitis: controls flaking and erythema on scalp and face - Pityriasis versicolor: restores normal skin pigmentation

Topical ketoconazole may cause local skin reactions and, rarely, systemic adverse events.

Common Side Effects: - Itching: mild to moderate pruritus at the application site - Burning sensation: transient heat feeling - Redness: localized erythema - Dryness: skin becomes flaky - Scaling: slight desquamation - Contact dermatitis: mild allergic response

Serious or Rare Side Effects: - Severe allergic reaction: swelling, hives, or anaphylaxis - Skin ulceration: breakdown of the epidermis - Photosensitivity: increased sunburn risk - Systemic toxicity: liver enzyme elevation with extensive use - Stevens‑Johnson syndrome: rare mucocutaneous blistering

When using topical ketoconazole, consider the following safety measures.

- Avoid use on broken skin: may increase systemic absorption - Do not apply near eyes or mucous membranes: risk of irritation - Check for hypersensitivity: discontinue if rash develops - Limit treatment duration: typically 2–4 weeks unless directed - Consult physician before combining with other topical agents: potential irritation - Store at room temperature: keep in original container, protect from moisture and light

Ketoconazole can interact with certain medications and treatments.

Major Interactions (Avoid): - Concurrent oral ketoconazole therapy: duplicate antifungal effect and increased toxicity - Use with systemic CYP3A4 inhibitors (e.g., itraconazole, erythromycin): may raise systemic ketoconazole levels - Co‑application with other potent topical antifungals: risk of excessive irritation

Moderate Interactions (Monitor Closely): - Topical corticosteroids: may mask signs of irritation - Phototherapy (UV light): can enhance skin sensitivity - Other hepatotoxic drugs (e.g., high‑dose acetaminophen): monitor liver function if extensive absorption occurs