Nitrofurantoin Pharmsol

Nitrofurantoin, the active ingredient in Nitrofurantoin Pharmsol, is a nitrofuran antibiotic presented as a 100 mg tablet for oral use. It treats uncomplicated urinary tract infections, primarily cystitis, in adult patients. GNH USA supplies Nitrofurantoin Pharmsol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Nitrofurantoin is indicated for bacterial infections of the urinary tract and related prophylaxis. - Uncomplicated urinary tract infection (cystitis): eradicates causative bacteria in the bladder, relieving symptoms. - Recurrent urinary tract infection prophylaxis: reduces the frequency of repeat infections when taken regularly. - Urinary tract infection in pregnancy (category B): provides a safe treatment option for pregnant women with cystitis.

Nitrofurantoin may cause a range of adverse reactions, from mild to severe.

Common Side Effects: - Nausea: mild to moderate stomach upset. - Loss of appetite: reduced desire to eat. - Headache: transient cranial discomfort. - Urine discoloration: brownish or yellow tint.

Serious or Rare Side Effects: - Pulmonary toxicity: interstitial lung disease or acute respiratory distress. - Hepatic injury: elevated liver enzymes or hepatitis. - Severe allergic reaction: rash, swelling, or anaphylaxis.

Before prescribing Nitrofurantoin, clinicians should consider several safety factors. - Renal function: assess creatinine clearance; avoid if severely impaired. - Pregnancy: category B, but avoid use in late pregnancy due to potential fetal harm. - G6PD deficiency: contraindicated because of risk of hemolysis. - Elderly patients: monitor for pulmonary and hepatic adverse effects. - Drug interactions: review concomitant medications that may affect absorption or metabolism. - Store at below 25°C: keep in the original pack, protect from moisture.

Nitrofurantoin can interact with other medicines, requiring careful management.

Major Interactions (Avoid): - Antacids containing magnesium or aluminum: markedly reduce nitrofurantoin absorption. - Warfarin: may potentiate anticoagulant effect and increase INR. - Methenamine: antagonistic effect, reducing antimicrobial efficacy.

Moderate Interactions (Monitor Closely): - Diuretics: may increase nitrofurantoin concentration and risk of toxicity. - Probenecid: decreases renal excretion, raising plasma levels. - Oral contraceptives: may reduce contraceptive effectiveness.